Staphylococcus Aureus Essay

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INTRODUCTION
Wound infections are one of the bad complications in patients undergoing surgeries. Consequently, infections of different organs or tissues that visible to surgeons may lead to significant increment of postoperative morbidity and mortality beside prolongation of hospital stay.1
It has been well documented that eradication of wound infection resulted in significant increment of patient comfort and decreased medical costs.2 Onche and Adedeji3 stated that Staphylococcus aureus is the predominate cause of surgical wound and nosocomial infections. Currently, the antibiotic drug resistance is a fast growing concern in wound infection management beside the risk of impairment of wound healing, bacteraemia, or even sepsis.4 National Nosocomial
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(Tanta City, Cairo, Egypt). Animals were housed in a room free from any source of chemical contamination, artificially illuminated and thermally controlled at the Animal
House Lab., Pharmacology and Chemistry Research
Centre, Misr University for Science and Technology (6th
October, Giza, Egypt). After an acclimatization period of 1 week, the animals were divided into four groups
(10 rats/group) and housed in filter-top polycarbonate cages (five rats per cage). All animals have received human care in compliance with the guidelines of the
Animal Care and Use Committee of the Pharmacology and Chemistry Research Centre (6th October City, Giza,
Egypt).
Infection Model
Circular Excision Wound Model
For the evaluation of the antibacterial activity, each rat was undergo anaesthesia by intraperitoneal injection of a combination of 10% ketamine hydrochloride (50 mg/kg) and 2% xylazine hydrochloride (5 mg/kg). The hair of the dorsal back of animals was shaved. For sterilization conditions, the sites of surgery were sanitized by povidone iodine followed by 70% ethanol solution. Circular incision was made on the dorsal inter-scapular region of

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