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Ziprasidone Lab Report

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Development and Validation of New HPLC method for Determination of impurities in Ziprasidone HCl
INTRODUCTION
Ziprasidone hydrochloride is chemically known as 5-{2-[4-(1,2-benzisothiazol-3yl)-1–piperazinyl]ethyl}-6-chloro-2-indolinonemonohydrochloride, monohydrate. It is used for the treatment of schizophrenia, mood disorders, acute mania, anxiety and mixed states associated with bipolar disorders. The oral form of ziprosidone was hydrochloride salt and intramuscular form was mesylate salt. Ziprasidone hydrochloride was approved by USFDA in the year of 2001 and was prepared on October 11, 2011 by Pfizer.
Method for development of robust stability - indicating method for analysis of Ziprasidone ( Hydrochloride and Free base)by UPLC was reported previously. method for development and validation of a rapid RP-HPCL method for the …show more content…

Ganji Ramanaiah,DR.D.Ramachandran,G Srinivas,V srilakshmi,Purnachanda Rao. Development and validation of a rapid RP-HPLC method for the estimation of Ziprasidone. Pharmacy and pharmaceutical sciences .2012:4(2):623-625
14. Ganji Ramanaiah, DR.D.Ramachandran,G Srinivas,Jayapal Gowardane , and purnachandra rao.development and validation of a Rapid UV-Spectroscopic method for the Ziprasidone Hydrochloride monohydrate In drug substance and its dosage forms. International Journal Of Pharmacy and Pharmaceutical sciences .2012:4(2):741-743
15. Sudheer Moorkoth,Swapnil Marghade,and Prashant B. Musmade. High performance liquid chromatographic assay for Ziprasidone in plasma samples: Application to pharmacokinetic studies in rats. Journal of Chromatographic science 2012:50:902-908
16. Sonam Mittal,Abhishek Guupta ,balasubramanian narasimhan, kona s . srinivas, ravi Shankar gupta,vinod Prasad semwal. Development and validation of stability indicating UPLC assay method for Ziprasidone. Active pharma ingredient chronicles of young scientists .2012:3(4):286=291
17. E Pushpa latha ,s Uma devi ,C.V.Nagendra kumar guptha , and

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