Aspirin Essays

  • Phosphoric Acid And Acetylsalicylic Acid Lab Report

    2007 Words  | 9 Pages

    V. Results and Discussion One of the objectives of this exercise is to synthesize acetylsalicylic acid (aspirin) from salicylic acid. The mechanism for this synthesis is through nucleophilic acyl substitution. Acetic anhydride was the acetylation reagent used with the salicylic acid. The mechanisms and the reaction involved in the synthesis are seen in the following figure. 1.00 gram of fine white salicylic acid powder was weighed in a clean, dry 125mL Erlenmeyer flask. 3mL of strong smelling

  • Synthesis Of Aspirin

    822 Words  | 4 Pages

    The chemical I will be looking at today is Aspirin. Aspirin is a medicine that was first produced 110 years ago. It came from salicylic acid found in plants such as the willow, and since then it has always been used. In 3000 BC the Egyptians used myrtle and willow to stop and reduce ones pains or fevers. In 30 AD Roman and Greek physicians discovered that the willow leaf could cure and help inflammation. There was one problem, the taste of the salicylic acid had a horrible taste causing vomiting

  • Thin Layer Chromatography Lab Report

    929 Words  | 4 Pages

    Thin Layer Chromatography (TLC) Abstract This experiment uses the TLC chromatography technique to identify the presence of acetylsalicylic and Acetaminophen in analgesic drugs (Tylenol and Anacin). It was found that the Anacin and acetylsalicylic had very closer Rf values (0.8 and 0.79). The Tylenol and acetaminophen had closer Rf values (0.54 and 0.58). Hence, Acetylsalicylic acid and acetaminophen were present in Anacin and Tylenol tablets respectively. Introduction Chromatography is the technique

  • Aspirin Synthesis

    864 Words  | 4 Pages

    Acetylsalicylic acid, or commonly known as “Aspirin” is widely used as a pain reliever, anti-inflammatory agent, and an antipyretic (fever reducer). Aspirin is a considered one of the most versatile drugs known to modern medicine. Aspirin’s active component, Salicylic acid, was initially isolated by Edward Stone. He isolated salicylic acid from the barks of a willow tree and derived from willow bark extracts. Salicylic acid is not used like it used to be because of the irritable effects it has

  • Commercial Headache Powder Lab Report

    1143 Words  | 5 Pages

    Aim This experiment separates the constituents of a commercial headache powder employing the use of extraction method. The active ingredients of the commercial headache powder were extracted by dissolving the powdered tablet in propanone solvent. The suspended fine particle binders in the propanone solution were removed by filtration method. The solid analgesia was obtained by evaporating propanone solvent. It was then collected on Hirsh funnel by filtration. Melting point determination was performed

  • Serratiopeptidase Essay

    1020 Words  | 5 Pages

    Development and Validation of Analytical Method for Simultaneous Estimation of Diclofenac potassium and Serratiopeptidase in Pharmaceutical Formulation Dhara Parekh*, Alpesh B. Limbasiya, Pankaj P. Kapupara, Ketan V. Shah Department of Quality Assurance, School of Pharmacy, RK University, Rajkot-360 020, Gujarat, India “*Address for correspondence”: School of Pharmacy, RK University, C/O: R.K. College of Physiotherapy Center, Near: Bhaktinagar Circle, Rajkot-360002, Gujarat

  • Salicylic Acid Investigation

    1308 Words  | 6 Pages

    concentration of salicylic acid, using the standard solution. b) To find the concentration of aspirin at the various time intervals using the molar absorptivity value in the previous part, initial concentration of aspirin and the concentration of salicylic acid obtained from the decomposition of the aspirin pill. c) Lastly, to calculate the rate constant of the decomposition of aspirin by plotting a graph of ln[aspirin] against time and making use of the gradient of the best fitted line along with the standard

  • Excedrin Synthesis Lab Report

    363 Words  | 2 Pages

    the compounds (aspirin, acetaminophen, and caffeine) were successfully isolated from the analgesic (Excedrin tablet). In figure 1, the separation of the compound in the TLC analysis correlates with the TLC analysis in figure 2. Furthermore, Rf index calculations of the TLC analysis demonstrated that the compounds (aspirin, acetaminophen, and caffeine) were separated. The Rf calculations of aspirin in table 1 shows an Rf value of .491; however, in table 2 the Rf value of aspirin was calculated to

  • Extraction And Synthesis Essay

    1705 Words  | 7 Pages

    Extraction is the process of removal or isolation of soluble substances from an insoluble residue either solid or liquid. Extraction can be done by treatment with appropriate solvents. There are various types of extraction method can be used in the pharmaceutical analysis field. The different types of extraction methods will be discussed below. Types of extraction methods: 1. Solid phase extraction (SPE) 2. Solid phase micro extraction (SPME) 3. Micro extraction by packed solid (MEPS) 4. Liquid-liquid

  • Essay On Ketoconazole

    724 Words  | 3 Pages

    Keywords: Ketoconazole, Antifungal agents, Optimization, Baker Lonsdale model, Peppas model, Higuchi plot INTRODUCTION The main objective was to design diffusion controlled microsphere drug delivery system of ketoconazole in order to sustain the delivery of the drug and thereby reduce the gastrointestinal disturbances and dose related adverse effects like hepatic dysfunction and allergic reactions as observed with conventional oral dosage form of ketoconazole (tablet). Ketoconazole microspheres

  • Glyphosate Research Paper

    1114 Words  | 5 Pages

    History of Glyphosate Commercial Use Glyphosate is a white crystal-like powder with the chemical formula of C3H8NO5P. Several researchers confirmed that glyphosate was synthesized in 1950 by Henri Martin who was working for a pharmaceutical company at that time (Alibhai and Stallings, 2001; American Chemical Society, 2010; Dill et al., 2010). In a separate research work conducted by the Monsanto Company, the chemists were able to discover two glyphosate-related chemicals that have weak herbicidal

  • Wet Granulation Case Study

    842 Words  | 4 Pages

    1. Allison Crouter and Lauren Briens, The Effect of Moisture on the Flowability of Pharmaceutical Excipients, AAPS PharmSciTech, Vol. 15, No. 1, February 2014. 2. Jinjiang Li and Yongmei Wu, Lubricants in Pharmaceutical Solid Dosage Forms, Lubricants 2014, 2, 21-43; doi:10.3390/lubricants2010021. 3. Wet Granulation: End-Point Determination and Scale-Up, Michael Levin, Ph. D. Metropolitan Computing Corporation, East Hanover, New Jersey, USA 4. Influence of drying temperature and granulation liquid

  • Mefenamic Acid Research Paper

    1071 Words  | 5 Pages

    Precautions Before Taking Mefenamic Acid Although mefenamic acid is a medication that may be bought over-the-counter, there are some things to keep in mind before taking it, including: • Tell your doctor/pharmacist if you are allergic to mefenamic acid, aspirin or other NSAID such as ibuprofen or naproxen. It is also safe practice to inform your doctor about other allergies because

  • Methyl Salicylate Case Study

    1647 Words  | 7 Pages

    Introduction Methyl salicylate is used as a local application for musculoskeletal pain. It is the main compound in oil of wintergreen. “One teaspoon of oil of wintergreen (5 mL) is equivalent to approximately 7000 mg of salicylate, or 21.7 adult aspirin tablets”.1 This concentrated liquid is readily absorbed via gut. Therefore, swallowing is lethal specially for children and there are numerous reports published [3]. There have been several deaths due to accidental ingestion of oil of wintergreen

  • Thin Layer Chromatography Essay

    1069 Words  | 5 Pages

    the edge of the silica TLC paper and divided into five parts with a ruler and a graphite pencil. One of the prepped silica TLC was used as the Reference Plate and the second as the Unknowns plate. The reference plate was spotted with Acetaminophen, Aspirin, Caffeine, Safinamide, and the standard reference mixture. The Unknowns plate was spotted with solutions identified as solution 1 through 4 and the last spot was spotted with the standard reference mixture. The micropipettes were used for spotting

  • The Pros And Cons Of Chelation Therapy

    988 Words  | 4 Pages

    What is chelation therapy? Chelation (pronounced key-LAY-shun) therapy is treatment used in conventional medicine for removing heavy metals (including mercury) from the blood. It involves intravenous injections of a chelating agent, EDTA (ethylene diamine tetra-acetic acid), a synthetic amino acid. EDTA binds to heavy metals and minerals in the blood so that they can be excreted in the urine. Another intravenous agent used by some physicians for mercury detoxification is called DMPS (2,3-Dimercapto-1-propanesulfonic

  • Doxorubicin Drug Analysis

    1543 Words  | 7 Pages

    Drug profile of doxorubicin Doxorubicin (DOX) also known as Adriamycin is categorized as anthracycline antiobiotic. It was first extracted from Streptomyces peucetius var. caesius by aerobic fermentation followed by solvent extraction and purification by chromatography in 1970s. It is also extracted from Streptomyces coeruleorubidus or chemically synthesized from daunomycin (its natural analog). DOX differes from daunorubicin only by a single OH group (Arcamone et al., 1972). DOX is a broad spectrum

  • Modamil Research Paper

    755 Words  | 4 Pages

    MODAFINIL:DRUG OF THE MODERN ERA Modafinil(commonly known by the brand names Provigil, Alertec, Modavigil etc) is an oral drug that is used to induce wakefulness in patients with sleepiness. It reduces fatigue and enhances alertness in an individual. It is also known as nootropic. It is usually taken once in a day with or without eating your meal. Modafinil is approved by the U.S. Food and Drug Administration for the treatment of narcolepsy or Obstructive sleep apnea hyperpnoea syndrome (OSAHS)

  • Aceclofenac: An Experimental Study

    1353 Words  | 6 Pages

    The present study relates to the stable fixed dose combination comprising of Aceclofenac as a glycolic acid ester of diclofenac having analgesic and anti-inflammatory action and Thiocolchicoside, as a glycosulfurated analogue of colchicine which is well known centrally acting muscle relaxant in unit dosage form and to the preparation method thereof. Aceclofenac is very susceptible to decomposition under hydrolytic, oxidative stress and exposure to light. The major degradation product identified was

  • Neevirapine Matrix Tablets Case Study

    746 Words  | 3 Pages

    6.2 Formulation development of Nevirapine matrix tablets. The formulation development of Nevirapine matrix tablets was started with using different viscosity grades of HPMC such as HPMC K4M, HPMC K15M, HPMC K100M and METALOSE 90 SH. MCC was used as diluent, water was used as the solvent to prepare the wet mass, talc and aerosil were used as anti adherent and glidant, magnesium stearate was used as lubricant. 6.2.1 Formulation development with HPMC K4M The formulation development was initiated with