Clinical trial protocol Essays

A new oral pharmaceutical drug for type- two diabetes had been approved for clinical use, it was called Compound 17392. Marketing companies instantly wanted to have prescribers adopt and sell the product and researchers wanted to further investigate previous reports of liver toxicity in patients. Now since paying patients to try new pharmaceutical drugs was an issue due to it appearing to interfere with clinical judgement and upholding the duty to do what is best for the patient, a new idea of

Ethics in Clinical Research Ethical Guidelines The goal of clinical research is to develop generalizable knowledge that improves human health or increases understanding of human biology. People who participate in clinical research make it possible to secure that knowledge. The path to finding out if a new drug or treatment is safe or effective, for example, is to test it on patient volunteers. But by placing some people at risk of harm for the good of others, clinical research has the potential to

risk should have considered when designing a randomized control trial. The fact that there is no clear understanding of what can the high-fiber supplement do to the subjects proves that this research is not ready to be piloted. A study was conducted to clarify the rules related to randomized control trials. The study concluded that, Participation in a randomized, controlled trial may pose no more than minimal risk when: 1) genuine clinical equipoise exists; 2) all of the treatment options included in

Chapter 5 Discussion 5. Discussion This trial was conducted to find out the efficacy of intensive strength training protocol over conventional physiotherapy treatment on balance, gait, and mobility in post stroke population. Totally 60 participants recruited from the population and randomly allotted into experimental and control group. The experimental group received intensive strength training to lower extremity, upper extremity and trunk muscles for 6 weeks, 6 days per weeks and 2-3 hours

Systematic review clinical assessment and evaluation of all studies that discusses the same clinical issue, simply its summary of outcomes of researched studies in a quantitative manner and hence it's named Meta analysis. After setting a question and searching for studies that meets the eligibility criteria and reading it very well to obtain adequate and precise results for Meta analysis detection of bias in the individual studies is an important issue to avoid inadequate results and to be sure

children. The Food and Drug Administration (FDA) requires that drugs be tested for safety and efficacy in a specific population, at a specific dosage, and for a specific time period before a drug is FDA approved for clinical use. Most clinical research for FDA approval protocol excludes children. Children are more vulnerable to adverse drug reactions and therefore

doctors to develop systems, equipment and devices in order to solve clinical problems. Biomedical engineering is the application of the principles and problem-solving techniques of engineering to biology and medicine. This is used throughout healthcare, from analysis and diagnosis to treatment and recovery. Biomedical engineers differ from other engineering disciplines that have an influence on human health in that engineers apply

1. Feed your ferret a premium ferret or premium kitten food (only if ferret food is not available). Make sure the food you choose contains at least 34% protein and less than 2% fiber. Make sure that meat is the first ingredient on the list of ingredients on the back of the bag. Avoid any ferret foods that contain dried fruits and vegetables. Remember, ferrets are strict carnivores! Suggestions: Totally Ferret, Zupreem, Iams Kitten, Eukanuba Kitten. 2. Give your ferret meat based treats or fatty

This study was conducted to evaluate the efficacy of 1% Alendronate gel and tetracycline fibers as an adjunct to scaling and root planing. The study was conducted on 30 subjects with a split mouth randomized controlled clinical design . The efficacy was determined based on the clinical parameters of the two groups that is Group I (treated by 1% Alendronate gel) and Group II (treated by tetracycline fibers).In order to overcome the drawbacks associated with systemic and conventional mode of therapy

KAWASAKI SYNDROME: A RARE CHILDHOOD DISEASE A Research Paper Presented to The Faculty of the Languages and Literature Department College of Medical Laboratory Sciences De La Salle Health Sciences Institute Dasmarinas, Cavite

Short Course Therapy Standardized short course regimens are an important element of DOTS. TB Programmers using short course therapies have consistently achieved higher cure rates than those relying on longer therapies. Short course therapies are more effective for two reasons: one, they are more efficacious; and two, compliance is higher. Importantly, short course therapies also reduce relapse rates and therefore multi-drug resistance. There is strong and consistent evidence that short course therapies

SITE SPECIFIC DRUG DELIVERY Site specific delivery systems are unique forms of delivery systems whereby the drug or medicine is specifically or selectively delivered to a particular site in the body where it is going to exert it's action and it is not delivered to other non-target organs and cells. The main aim of site specific delivery of drugs is to develop drug concentration that is sufficient to produce therapeutic effect at the site of the disease with minimal effect to the rest of the organs

significant bone defects (humeral and/or glenoid greater than 20%), presence of clinical signs of posterior or multidirectional instability

DISSECTION METHOD TO APPROACH THE HUMAN CORACOID PROCESS OF THE SCAPULA 3.1 Introduction Dissection is a traditional approach to medical laboratory education(Waters, 2008). Using human cadavers one of the most widely used model in medical and clinical research for several decade .Considerable amount of literature have been published on different dissection methods of human body .(Romanes et al.,1986;Tank et al.,2008). These currant dissection manuals showed different approach to access different

Efficacy And Safety Of Post-Cesarean Section Incisional Infiltration With Lidocaine Alone Versus Lidocaine And Epinephrine In Reducing Postoperative Pain: A Randomized Controlled double-blinded Clinical Trial Ahmed A. Tharwat (MD)*, Amr H. Yehia (MD, MRCOG)*, Karim A. Wahba(MD, MRCOG)*, Abd-ElRahman G. Ali (MSc.)** * Department of Obstetrics and Gynecology Ain Shams University Maternity Hospital ** Department of Obstetrics and Gynecology Misr Al-Gededa Military Hospital Correspondence : Dr Karim

Comparative Study Between Tramadol And Combination Of Acetamlnopheffl-Famoticlniiie In Laparoscopic Cholecystectomy Magdy El Babiy; Atef Zarzour; Ashraf El Zeftawy & Hesham El Sheikh Department of Anesthesiology, Faculty of Medicine -Tanta University ABSTRACT Background: This study evaluates the antacid and analgesic effects of single i.m dose of tramadol given 1hour before induction of general anesthesia for laparoscopic cholecystectomy. Intramuscular tramado lincreases gastric pH and reduces gastric

Objectives The objective of this experiment is to perform Quality Control (QC) tests to assess if the Acetaminophen sample prepared by previous polytechnic students during their internship is in compliance with the monograph in the British Pharmacopoeia (BP). There were 3 different samples prepared A, B, and C. My group and I performed the experiments using sample B. For drugs to be deemed suitable for public consumption they must meet certain criteria to ensure that they will not cause more harm

mends the Controlled Substances Act to increase the number of patients that a qualifying practitioner dispensing narcotic drugs for maintenance or detoxification treatment is initially allowed to treat from 30 to 100 patients per year. Allows a qualifying physician, after one year, to request approval to treat an unlimited number of patients under specified conditions, including that he or she: (1) agrees to fully participate in the Prescription Drug Monitoring Program of the state in which the

In clinical trials, efficacy and safety are measured by means of certain predetermined endpoints, or outcomes. The main objective of a Phase 3 trial is to demonstrate the efficacy of a drug in the actual target population that is proven in a statistically and clinically significant manner. A Phase 3 trial has a clearly defined primary endpoint(s), pre-specified even before study initiation, because they will determine the power of the study and ensure that the research question is specific. Clinical

It was interesting to learn the process of how a central nervous system (CNS) drug is approved. The fact of only about 8.2 percent of CNS drugs make it to clinical trials, while 15 percent of other types of drugs make it. CNS drugs seem to be more regulated, as it has a high risk due to its potential effects on the brain and spinal cord. There’s no telling what the drug can actually do to the CNS, until it is administered. Priority review or the fast track application are two options to speed up