TERMINOLOGY CLINICAL CLARIFICATION 6 • Ambiguous genitalia (also called disorders of sex development or DSD) is a diverse catalog of congenital anomalies that encompasses genotype and phenotype irregularities, endocrine abnormalities and enzymatic dysfunctions in the organs that express human sexual identification. These include male and female pseudohermaphroditism, gonadal dysgenesis, and true hermaphroditism. CLASSIFICATION 4 • Formal taxonomy of disorders of sex development (note that some
Therefore, patients on the conventional therapy and PCMs are have reduced compared to conventional therapy alone (van Dijk et al 2006). Medication can be prescribed for a patient with vasovagal syncope. The patient could take Fludrocortisone (mineralocorticoid) tablet results in the retention of water and sodium and exertion of potassium thus increasing blood volume. However a double randomised placebo-controlled test has shown to the patients on the Fludrocortisone have been more symptomatic than
Sodium (Electrolyte) Balance – Physiologists often refer to sodium as the backbone of the extracellular fluid and emphasize that water follows sodium. Although separate hormonal axes exist for water and sodium reuptake, sodium plays a crucial role in maintaining intravascular fluid volume in addition to contributing to serum osmolality. As will be explained, the kidneys conserve much of the water (a.k.a. plasma volume) in the glomerular filtrate by retaining sodium. Serum sodium concentrations must
AGE RELATED CHANGES IN ENDOCRINE SYSTEM Adil Jumani-2015M063 1. Describe the effect of aging on the functions of the endocrine pancreas. Aging of the pancreas is usually divided into two main groups- endocrine and exocrine aging. The endocrine part of the aging mainly includes impairment in the function of beta cells which leads to a decrease in the formation of insulin from proinsulin, also leading to an abnormal secretion of insulin. These impairments in the beta cells are due to lipid
The human body is an extremely complex system made up of many different components. In order for it to function at its highest level, measures of protection to both the internal and external environments needs to take place if the body is to survive. This process is called homeostasis. Although homeostasis is able to play its role in the human body for the majority of the time, in some circumstances it is unable to function properly due to either internal or external factor effecting one or more
The kidney is one of the vital organs for excretion in the human body. Kidneys are paired; reddish, bean-shaped organ located at the back of the abdomen, one on each side of the spine, at the level of the lowest ribs, just above the waist between the peritoneum walls of the abdomen. The right kidney is slightly lower than the left kidney because the liver occupies considerable space on the left side superior to the kidney (Figure: 1.1). Kidneys are situated retroperitoneal in the abdominal cavity
Possible Advantages of the Physicochemical Properties The active ingredient of the drug is the acetyl ester of abiraterone. Abiraterone acetate is a white, non-hygroscopic, crystalline powder. Its molecular formula is C26H33NO2 and it has a molecular weight of 391.55. Abiraterone acetate is a lipophilic compound with an octanol-water partition coefficient of 5.12 (cLog P) and is practically insoluble in water (U. S. Food and Drug Administration/Center for Drug Evaluation and Research, 2012). Based
messenger within the cell where it binds to a second receptor to change the function of the cell’s physiology. Lipid-soluble hormones: Lipid-soluble hormones include the steroid hormones such as testosterone, estrogens, glucocorticoids, and mineralocorticoids. Because they are soluble in lipids, these hormones are able to pass directly through the phospholipid bilayer of the plasma membrane and bind directly to receptors inside the cell nucleus. Lipid-soluble hormones are able to directly control
A.H is a twenty-seven-year-old Arabic speaking mother who was admitted October 4, 2015 for fetus delivery. Gestation at this time was 40 weeks and one day. Her last menstrual period was December 30, 2014. Her Gravida ( G), Term births (T), Preterm Birth ( P), Abortions (A) and Living children (L) is 2/2/0/0/2. She gave birth to R.H, a beautiful baby girl, October 5, 2015 at 0817. R.H was 7 pounds, 15 ounces and 20 inches long. She had a normal spontaneous vaginal delivery. The baby was a normal