Sitagliptin Essays

  • Psy 6510 Final Exam

    1540 Words  | 7 Pages

    Ameya J. Limaye PMCY 6510 Take Home Final Exam A. Reference drug product: Janumet XR (sitagliptin phosphate and metformin HCl extended release tablets) Selected dosage strength: 50mg sitagliptin, 500mg metformin (once daily for naïve patients currently not treated with metformin) B. Active pharmaceutical ingredients: 1. Sitagliptin: Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Inhibition of DPP-4 prevents breakdown of GLP-1and GIP and allows for an extended

  • Januvia Drug Synthesis Essay

    538 Words  | 3 Pages

    (API), sitagliptin (Taylor, 2012). This way of production required a high pressured hydrogen environment and the use of a metal catalyst. The final stage of production also required an energy consuming recrystallization step to take away the remaining catalyst. I In order to have a more efficient production, Merck and Codexis, two pharmaceutical companies, mutated transaminase enzyme to catalysis the transfer of amino group. The use of this enzyme helps improve the yield for sitagliptin by converting

  • Combination Therapy Research Paper

    539 Words  | 3 Pages

    glucose produced by cells in the liver. Additionally, it makes the muscle cells sensitive to insulin and finally it slows the absorption of glucose from the intestines into the blood after food consumption. • Januvia (the active ingredient is sitagliptin)- it belongs to a class of medication by the name DPP-4 inhibitor. It lowers blood glucose levels by hindering breakdown of two incretin hormones by the name glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). The

  • Normal Glucose Homeostasis Summary

    3602 Words  | 15 Pages

    KIDNEY AND TYPE 2 D.M Normal Glucose Homeostasis Normal Glucose Homeostasis reflects a Balance of glucose Production, absorption, and Excretion • A delicate balance between several regulatory processes maintains glucose within a narrow range of ~80-120 mg/d L throughout the day • Hormonal regulation – Insulin: glucose utilization and production – Glucagon: hepatic glucose production (together with insulin) • Organs – Liver: glucose production (via glucose formation and formation of glucose

  • Pharmacoeconomic Analysis Model

    1324 Words  | 6 Pages

    Aim: To conduct pharmacoeconomic evaluation of oral-hypoglycemic agents using cost effectiveness analysis. Methodology: The study was conducted in a hospital at Bangalore for 9 months period. In-patients who were diagnosed with type 2 Diabetes Mellitus (type 2 DM) and were receiving treatment specifically with oral-hypoglycemic agent(s) were included in the study. Various treatment-related expenses were determined and tabulated from patient case note. The data obtained was introduced to cost-effectiveness