Solubility Essays

  • Solubility And Solubility Product

    1674 Words  | 7 Pages

    SOLUBILITY AND SOLUBILITY PRODUCT OBJECTIVE In this experiment you will determine the solubility and solubility product of a sparingly soluble salt, potassium hydrogen tartrate, and also in four solutions containing a common ion. INTRODUCTION When a salt of low dissolubility dissolves in water, equilibrium is established between the solid solute and the dissolved ions. There are two terms used in discussing this condition. The first is solubility, which is the maximum amount of salt that will

  • Essay On Solubility

    1230 Words  | 5 Pages

    Solubility of a Salt Introduction: The solubility of a pure substance in a particular solvent is the quantity of that substance that will dissolve in a given amount of a solvent. Solubility varies with the temperature of the solvent. Thus, solubility must be expressed as quantity of solute per quantity of solvent at a specific temperature. For most ionic solids, especially salts, and water, solubility varies directly with the temperature. That is, the higher the temperature of the solvent (water)

  • Solubility Lab Report

    1004 Words  | 5 Pages

    Solubility Enhancement by Chemical Modification Method Abstract Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system. It is an important parameters to achieve optimum concentration of drug in systemic circulation for desired pharmacological response. Oral route is the most desirable and preferred method of administering therapeutic agents for their systemic effects, but poor solubility of drug major problem encountered with formulation development

  • Experiment 5: Study Of Solubility Equilibrium

    1995 Words  | 8 Pages

    5: Study of Solubility Equilibrium Aim To determine the solubility product constant Ksp of a sparingly soluble salt potassium hydrogen tartrate (KHC4H4O6) in water To calculate the change in enthalpy (ΔH° reaction) and entropy (ΔS° reaction) of the reaction Results and Discussion The dissociation reaction of potassium hydrogen tartrate (KHC4H4O6) in water can be written as: KHC4H4O6 (aq) ⇆ K+ (aq)  HC4H4O6- (aq) Determination of Ksp at 284 K The expression of its solubility product constant

  • Melting Point Solubility Lab Report

    1257 Words  | 6 Pages

    type of chemical (ionic, molecular, macromolecular and metallic) has its own set of properties, by testing these properties and finding them out for each chemical, it was possible to classify them. The properties tested during this experiment were solubility in water, toluene, and ethanol and the electrical resistance for those soluble in water. The melting point was tested for the two unknown chemicals. II. MATERIALS AND PROCEDURES List of chemicals used: Sodium nitrate,

  • High Solubility Research Paper

    1645 Words  | 7 Pages

    2.3 SOLUBILITY 2.3.1 Introduction [6] Drug solubility is the greatest concentration of the drug dissolved in the solvent under specific condition of temperature, pH and pressure. As solubility is an important determinant in drug liberation hence it plays a key function in its bioavailability. For absorption of any drug it must be present in the form of an aqueous solution at the site of absorption. About 40% of all new chemical entities have poor bioavailability. The bioavailability can be increased

  • Determination Of A Solubility Reaction Lab Report

    1001 Words  | 5 Pages

    DETERMINATION OF A SOLUBILITY PRODUCT CONSTANT Introduction Parsimoniously soluble ionic solids, when placed in water, go through an equilibrium reaction. This equilibrium reaction is the same as a hypothetical reaction of solid, WxZy as shown in equation 1. WxZy (s)↔xWy+ + yZx- ………………………………………….. Equation 1 From equation 1, the equilibrium constant (Keq) of any reaction is called Ksp (solubility product constant) of the ionic solid. Fundamentally, solubility product constant is the quantification

  • Hydrochloric Acid Synthesis Lab Report

    1680 Words  | 7 Pages

    Indomethacin tablets through microwave radiation 1. Introduction Biopharmaceutical classification system Class I High solubility High permeability Class II Low solubility High permeability Class III High solubility Low permeability Class IV Low solubility Low permeability A majority of the active pharmaceutical ingredients (APIs) in the research and development have poor aqueous solubility. However, the poor dissolution rate characteristic of relatively insoluble BCS class II substances has long been

  • Calorimetry Lab Report Essay

    1908 Words  | 8 Pages

    A sample Calculation Calculation of the dissolved amount: Initial weight - Weight of substances left after the solution reached saturated state = Dissolved amount of substance Calculation for the average of three trials: (Data of 1st trial + Data of 2nd trial + Data of 3rd trial) / 3 = Average Appropriate Graph(s) For Electrical Conductivity Experiment: Raw Data Table (Credit: Cynthia, Emily, Haruka, Joshua, Keimin, Sean, Reorganized by me) Qualitative Observations No qualitative observation

  • Kneading Technique Lab Report

    3676 Words  | 15 Pages

    1. INTRODUCTION 1.1. CYCLODEXTRIN1, 2, 3:- For drugs to be pharmacologically active, they essential have assured degree of water solubility, and also maximum of them should be lipophilic in instruction to be permeable to the biological membranes through passive diffusion. The water solubility of drug is characterized by its potency and its type of formulation. The hydrophilic property will prevent the dissolved drug molecule to separate from the hydrous exterior into a lipophilic bio membrane and

  • Emulsion Classification Lab Report

    800 Words  | 4 Pages

    strong or weak in both cases it depend on magnitude of attractive forces involved in it. 3. Ostwald Ripening (Disproportionation) This process results due to finite solubility of both the liquid phases. Liquids which are immiscible have mutual solubility that is not count far. The emulsions which are polydisperse, have larger solubility because of smaller droplets when it will compared to the larger droplets this all due to curvature effects. After sometime these smaller droplets diffuse into bulk

  • Itraconazole Feasibility Study

    754 Words  | 4 Pages

    Itraconazole, a BCS Class II drug has poor aqueous solubility leading to poor bioavailability. The objective of the present investigation was to formulate Itraconazole Liquisolid compacts to enhance its oral bioavailability. Optimized formulation was prepared using PEG 600 as non-volatile solvent, Alfacel PH 200 as carrier and Aerosil 200 as coating material by using Mathematical model for designing the liquisolid systems. The free flowing dry powder blend was then compressed into tablets and evaluated

  • Solid Phase Extraction (SPE)

    1150 Words  | 5 Pages

    Generally, the 2 immiscible phases are aqueous and organic solvent. Besides, it can be stated as the ratio, K, where solubility of analyte dissolved in organic phase (g/100ml) to the solubility of solute dissolved in aqueous phase (g/100ml). 3. Hot Continuous Extraction (Soxhlet) This is a continuous extraction method using a hot solvent, which the extracting phase will be passed continuously through the

  • Odourless Powder Essay

    1255 Words  | 6 Pages

    above results it is evident that OXB exhibits poor flow properties. 8.1.2 Determination of solubility The solubility data for OXB as observed in 0.1 N HCl, pH 4.5 Acetate buffer, pH 6.8 Phosphate buffer and Purified water is presented in Table 25. OXB exhibited a pH independent solubility phenomenon in all pH conditions and various aqueous buffers. Table 25: Solubility data of OXB BCS solubility (pH solubility) profile of OXB Sr. No Media mg / ml 1 0.1 N HCl 249.119 2 pH 4.5 Acetate buffer

  • Extraction And Synthesis Essay

    1705 Words  | 7 Pages

    Extraction is the process of removal or isolation of soluble substances from an insoluble residue either solid or liquid. Extraction can be done by treatment with appropriate solvents. There are various types of extraction method can be used in the pharmaceutical analysis field. The different types of extraction methods will be discussed below. Types of extraction methods: 1. Solid phase extraction (SPE) 2. Solid phase micro extraction (SPME) 3. Micro extraction by packed solid (MEPS) 4. Liquid-liquid

  • Liquisolid Techniques Lab Report

    1620 Words  | 7 Pages

    compatibility for liquisolid powder formulation and that in turn will increases the weight of each tablet above 1 gm which is very difficult to swallow. 2.5.5 Mechanisms of Enhanced Drug Release from Liquisolid Systems [15] • Increased Aqueous Solubility • Increased Drug Surface

  • Recrystallization Of Acetanilide Essay

    920 Words  | 4 Pages

    suitable solvent being chosen and proper recrystallization technique being carried out. The solvent chosen had to have a different polarity than that of the molecule of interest. The technique used was dependent on the solubility of the solvent at higher temperature and the solubility of the impurities at all temperatures. To analyze the acetanilide product of the reaction, 1H NMR and IR were used. Results, Discussions, and Conclusions In this experiment, acetanilide was synthesized via

  • Emtricitabine Case Study

    937 Words  | 4 Pages

    4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one c) Molecular Formula: C8H10FN3O3S d) Molecular Weight: 247.248 g/mol e) Description: white to off-white crystalline solid f) Melting point: 136 °C to140 °C g) Solubility: Freely soluble in methanol and in water; practically insoluble in methylene chloride. h) pKa value: 2.65 i) Route of administration: Oral j) Excretion: Renal (86%) and fecal (14%) k) Metabolism: Hepatic oxidation and glucuronidation CYP system

  • Monocrotopos Research Paper

    908 Words  | 4 Pages

    dimethyl[(E)-4-(methylamino)-4-oxobut-2-en-2-yl]phosphate Molecular formula: C7H14NO5P Molecular weight: 223.2 Structural formula: CAS number: 6923-22-4 Physical properties: (Tomlin, 1997) Boiling Point: At 0.07 Pascal 125oC Melting Point: 54-55oC Vapor Pressure: 3*104 Pascal Solubility in water: miscible Log Poctanol/water: -0.22 Chemical properties: Pure Monocrotophos is in crystalline form. Crystals are colorless and hygroscopic in nature. Commercial product is a clear viscous liquid which is reddish brown to dark brown in color

  • Disadvantages Of Reverse Osmosis

    1639 Words  | 7 Pages

    Reverse osmosis (RO) is the leading desalination technology around the globe and is used to remove different types of ions, molecules and larger particles from solvents (e.g. water). In the standard osmosis process, a solvent naturally moves from an area of low solute concentration, through a semipermeable membrane, to an area of high solute concentration. By equalizing the solute concentrations on each side of the membrane, an osmotic pressure is created. In order to obtain clean water, a pressure