Advantages of Co-crystals:
Co-crytals have benefits like stable crystalline type compared to amorphous solids, no need to make or break covalent bonds, theoretical capability of all types of API molecules (weakly ionizable/non-ionizable) to form co-crystals, the existence of diverse potential counter-molecules (food additives, preservatives, pharmaceutical excipients, and different APIs), the sole solid type that 's designable via crystal engineering patentable increasing information science portfolios and can be produced using solid-state synthesis green technologies high yield, no solvent or by-products.
Solvates and Hydrates:
From a systematic factor of view, solvates such as hydrates may be taken into consideration as a subgroup of cocrystals. The solvent, or the water, acts as a co-former. Such forms may be the result of a design to attain crystals with sure properties, but they will additionally be the result of a diffusion of a final solvent based totally on different criteria. with a view to distinguish hydrates and solvates from (different) cocrystals it 's been suggested to limit the definition of cocrystals by means of pointing out that the components of a cocrystal need to exist as character solids at ambient conditions. This has been criticized due to the fact that not simplest solvents, however also different capacity co-formers as well as the active substance itself can be drinks at ambient temperature (e.g. valproic acid9,10). It consequently appears to be of