Azo coupling Essays

Kolbe-Schmitt Reaction Kira Wall (CHE433) 12-3-14 The Kolbe-Schmitt reaction is named after Hermann Kolbe and Rudolf Schmitt. Schmitt published his research in the Journal fur Pracktische Chemie in 1885 while Kolbe published his research in the Annalen der Chemie und Pharmacie in 1860. The reaction adds a carboxyl group onto the benzene ring of a phenol. The process uses a base carbon dioxide and acid work-up. The original reaction done by Kolbe involved the formation of sodium phenoxide

to benzopinacolone by heating under reflux (5 minutes) with glacial acetic acid containing trace amount of iodine dissolved in it. This reaction is known as pinacol- pinacolone rearrangement. Step I: Preparation of benzopinacol from benzophenone : Coupling reaction Reaction: Procedure: 1. Take a mixture of 1.5 g of benzophenone , one drop of glacial acetic