Description Description Organophosphate poisoning results from exposure to organophosphates (OPs), which cause the inhibition of acetylcholinesterase(AChE), leading to the accumulation of acetylcholine (ACh) in the body. Organophosphates and carbamates are the most frequently used insecticides worldwide. These compounds cause 80% of the reported toxic exposures to insecticides. Organophosphates produce a clinical syndrome that can be effectively treated if recognized early. The typically described
Urea cycle Introduction The task of urea cycle is to avoid the amassing of toxic NH4+. It incorporates nitrogen not used for biosynthetic purposes into urea, which serve as the waste nitrogen produce in mammals. Urea is the major disposal form of amino groups derived from amino acids, and account for about 90% of the nitrogen-containing gears of urine. Also urea cycle is accountable for de novo synthesis of arginine. The complete Urea Cycle is by far only in liver. However, some enzymes of the
Some commercial products also contain organophosphorus or Carbamates insecticides in that time person can have mixed signs. Common causes of death in cases of pyrethroid poisoning are allergic reactions, respiratory failure (hypersensitivity pneumonitis, pulmonary oedema, seizuers, secondary pneumonia and coma. Atypical presentations can occur with the pyrethroid poisoning where patients present with respiratory failure requiring mechanical ventilation, hypotension, pneumonia, acute kidney injury
homologous to the biotin family of enzymes. Carbamoyl phosphate synthetase I activates bicarbonate by phosphorylation with ATP to form carboxyphosphate. Ammonia then reacts with carboxyphosphate to from a carbamate intermediate. A second molecule of ATP is used to phosphorylate the carbamate intermediate to form carbamoyl phosphate. Carbamoyl phosphate synthetase I is the first committed step of the urea cycle. As one would expect this enzyme is allosterically regulated. This enzyme is allosterically
The medical field is always expanding with new research to treat and fight illnesses and severe conditions. There comes a point where certain people have no options left and the only option could be an illegal treatment. One of these treatments is known as medical cannabis, or medical marijuana. Marijuana is illegal on the federal level, however there are certain states that have legalized it for its medical purposes. This has caused families to move across the United States to receive treatment
Dog flea control and management requires an integrated approach. For effective treatment both the host animal and the environment must be treated at the same time. Control of fleas on the pet generally requires the use of insecticides. Although flea combs can remove some fleas, combing should be thought of as a method for detecting fleas rather than removing them. If an animal is to be treated for other conditions besides fleas, such as expression of anal glands, these procedures should be done
INTRODUCTION: Poisoning is a significant global public health problem. According to WHO data, in 2012 an estimated 193,460 people died worldwide from unintentional poisoning. Of these deaths, 84% occurred in low and middle-income countries. Nearly a million people die each year as a result of suicide, and chemicals account for a significant number of these deaths.1 According to the world health organization (WHO), 99 per cent of the fatal poisoning cases occur in developing countries.2 A poison
One of them showed swollen pancreas on ultrasonography which was confirmed by Computerised Tomography. In other two patients, evidence of pancreatitis was not observed. There was no significant correlation between the nature of compounds (OP or carbamates), duration and severity of cholinergic syndrome and increase in serum Amylase. It has been concluded that mild elevation of serum Amylase is common in patients with OP poisoning, however acute pancreatitis is rare
Aldol condensation In the aldol condensation the α-carbon of one aldehyde or ketone molecule adds to the carbonyl carbon of another. The base is most often used is -OH. The product is a β-hydroxy aldehyde or ketone, which in some cases is dehydrated during the course of the reaction. Even if the dehydration is not spontaneous, it can usually be done easily, since the new double bond will be in conjugation with the C=O bond. Ritter Reaction Alcohols is converted by a strong acid to a carbocation
1.3. An Overview for the Synthesis of Tetrahydropyrans, Piperidines and Dihydro-γ-pyrone Derivatives To build this class of heterocycles, many strategies have been developed over the years. The most widely used methods are the Prins cyclization, hetero-Diels–Alder (HDA) cyclization, oxonium-ene cyclization, the intramolecular Michael additions and ring-closing metathesis. Other strategies include electrophile-induced cyclizations of non-activated alkenes and Lewis acid promoted cyclizations of epoxy