The reaction represents a biochemical shunt of the respiratory electron transport chain carrying electrons from the level of reduced flavin directly to oxygen. FMNH2 reacts first with oxygen to form a linear hydroperoxide which then reacts with long chain fatty aldehyde to give peroxyhemiacetal intermediate. This breaks down to give long chain acid and the intermediate hydroxyflavin in
Docking studies of Nitroimidazo-oxazine with Pyridoxine 5'-Phosphate Oxidase M Sathish kumar1 , UCA Jaleel2 CSIR OSDD Research Unit , Bangalore Abstract Mycobacterium tuberculosis continues to be one of the world’s most debilitating and deadly pathogens. PA-824 is a nitroimidazole that has demonstrated bactericidal and sterilizing activity against drug-resistant and non drug-resistant tuberculosis. PA-824 is activated by either a bacterial enzyme or a cofactor, which is a compound that binds
Question 2 - Inosine in AMP catabolism Introduction Adenosine monophosphate (from now on referred to as AMP) is the lowest energy-containing nucleotide found in living organisms. In its degradation process (Figure 1), several enzymes and intermediates are required, playing important roles that regulate the correct functioning of the overall process. An alteration in any of those participants can cause severe consequences, such as immunosuppression. Inosine is one of those previously mentioned intermediates