The diseases are caused by defects in any one of 13 genes termed by PEX genes. Those genes required for the natural synthesis and function of peroxisomes. Peroxisomes are required for normal brain development, function of formation of myelin, the whitish substance that coats nerve fibers. They are also helpful for normal eye, liver, kidney, and bone functions. Once a person with Zellweger syndrome has been born, peroxisomes is finish, damage kidneys, liver and white matter in the brain.
Platelets help control bleeding in an interesting process call hemostasis 3. In this process when an injury occurs to a blood vessel, causing bleeding the platelets start to stick to the injured blood vessel and release chemicals to attract other platelets. 4. Then as more platelets start sticking together they soon form a temporary clot V. The blood vessels guide blood and help the blood travels through our body. A.
Introduction Thrombocytosis is when you have too many platelets (thrombocytes) in your blood. Platelets are parts of blood that stick together and form a clot (thrombus) to help your body stop bleeding. Some conditions that cause inflammation, such as cancer, may trigger your body to make more platelets than normal. There are two types of thrombocytosis. Primary or essential thrombocytosis happens when abnormal cells in the bone marrow make too many platelets.
Mutations are, mostly, deletions of one or more exons that interrupt the open reading frame of the transcript and eventually stop the synthesis of the dystrophin protein. Drisapersen, an RNA-modulating therapy, skips the exon 51 in dystrophin pre-mRNA. By skipping one or more exon(s), there is re-establishment of the open reading frame, followed by production of novel shortened dystrophin. By the production of dystrophin, the severity of Duchenne is reduced and it is converted into a milder Becker Muscular Dystrophy
These Include: Coronary Heart Bypass Surgery ( Bypass Graft) - the blood vessel is removed or redirected from one area of the body and placed around the area or areas of narrowing in order to "bypass" the blockages and restore blood flow to the heart muscle. This vessel is called a graft. These substitute blood vessels can come from your chest, legs, or arms. They're safe to use because there are other pathways that take blood to and from those tissues. The surgeon will decide which graft(s) to use depending on the location of your blockage, the amount of blockage and the size of your coronary arteries.
FIG : NORMAL HEART FIG : HYPERTROPHIC HEART (Hypertrophic cardiomyopathy,Cleveland clinic) Above figure in the left shows physiology of the normal heart while the right one shows physiology of hypertrophic heart having leaky mitral valve, thickened septum and narrowed outflow tract. Symptoms of hypertrophic cardiomyopathy: (Marian Ali .,2010) • Arrhythmias: This condition mainly occurs when heart rhythms of the patient are irregular due to improper flow of blood from the heart to rest of the body. This could further lead to cardiac failure along with sudden death of the patient. • Syncope: It does not occur frequently but usually in patients having left ventricular outflow
it\'s going to result to associate infection within the muscle as a result of a illness of the arteries, interference the guts valves and also the likes. medication is also prescribed to assist one with this type of issues. Pulmonary valve stricture (PVS) This condition happens once there\'s a thickening of 1 or additional valves within the heart cavity. this could result in blockage of the guts between those within which the condition has progressed in DVE a amount of your time. Heart attack A coronary failure is that the results of plaque within the arteries designed, And by inflammation, therefore referred to as coronary-artery disease.
The loose blood clots can block the artery in the heart and become pulmonary embolism (PE). A pulmonary embolism is dangerous conditions that can lead to fatal because of blood supplies from the heart to the other parts of the body are failed. DISEASE CLASSIFICATION Deep vein thrombosis can be classified to three categories which is idiopathic, acute and chronic. Idiopathic deep vein thrombosis can characterized with usual condition acquired risk factors, such as obesity, trauma, cancer, or surgery. Acute deep vein thrombosis can be seen by pain and swelling.
When the blockage is temporary or partial, angina (chest pain or pressure) may occur. When the blockage completely and suddenly cuts off the flow of blood, the result is myocardial infarction. Congenital defects and spasms of a coronary artery may also block blood flow. There is evidence that infection from organisms such as chlamydia bacteria may be responsible for some cases of coronary artery disease. A number of major contributing factors increase