Purpose The aim of this experiment is to an amide is created by treating an amine with acid anhydride during acetaminophen preparation. Acetaminophen (p-acetamidophenol), the amide, is produced when the amine p-aminophenol is subjected to treatment by acetic anhydride. Experiment Data/Results We started this experiment by obtaining a 50 mL Erlenmeyer flask so we are able to transfer the compounds needed for this reaction mixture. We weighed about 1.5008 grams of p-aminophenol and placed this directly into the Erlenmeyer flask. By using a graduated cylinder, we obtained 4.5 mL of water and 1.7 mL of acetic anhydride, followed by the addition of a magnetic stir bar into our Erlenmeyer flask. Once we have all the components we need in the …show more content…
It can be administered to patients with mild to moderate pain by itself or in conjunction with an opioid analgesic for severe pain. The mechanism of …show more content…
We added a magnetic stir bar to mix the components thoroughly for the next step of heating them. Since this mixture is a reaction mixture we are going to use a hot plate to heat up the reaction mixture at about 90 ℃. The reason why we are using this temperature range is due to the fact of p-aminophenol has a boiling point of 284 ℃. We only need a certain amount of heat to keep the p-aminophenol and force the mixture to react with the heat, the best temperature range is 90-100 ℃ for this reaction mixture. We observed the reaction mixture temperature carefully by using a thermometer so the temperature does not go lower or higher than the desired temperature range. If this were to happen, the reaction mixture would produce a completely different reaction or a certain component would have been missing (dissolved) within the reaction mixture. Throughout the heating process, we observed the solid being dissolved, precipitated, and, redissolved. This was able to happen because paracetamol and acetic acid are the byproducts of the primary reaction that occurs when p-aminophenol and acetic anhydride react. This response is completed in three unique solvents; iso-amyl alcohol, water, and 2-propanol. In addition, the reaction can be carried out with or without impurities. The hydrolysis reaction between acetic anhydride and water produces H+ when water is
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The purpose of this lab is to use the Diels-Alder reaction to combine anthracene and maleic anhydride. Named after its two founders the Diels-Alder reaction is the addition of a conjugated diene (electron rich compound) with a dienophile (electron poor compound). (1) These compounds will be combined using [4+2] cycloaddition, where the numbers 4 and 2 come from the number of π electrons that are used in each compound to synthesize the product. (2) This experiment comes at the cost of losing two π bonds to form two new sigma (σ) bonds in the cyclic compound. (2)
Structural Features Acetaminophen is a molecule that is made of twenty atoms; its bonds consist of fourteen single bonds and four double bonds. Acetaminophen is also composed of clusters atoms with groups with names. First of all, part of an acetaminophen atom is a benzene ring. A benzene ring is a ring of six carbon atoms that are connected to each other by three double bonds and three single bonds and unusually all the bond are the same size. In addition, to make sure all the electrons in the outer valence are used the there are hydrogen atoms bonded to stabilize the carbon atoms.
Purpose: The main goal of this lab experiment is to synthesize acetylsalicylic acid through using different processes such as crystallization and filtration. Additionally, determining the purity of the synthesize product alongside with a commercial ASA provided in the lab, through using one of the melting point apparatus or conducting a USP test are also the objectives of this experiment. Results Discussion: As discussed in the lab manual, there are certain instructions which apply to proper measurement to provide accurate values throughout the experiments. For example, the transferring of 10 ml of ASA solution to a vial tube by volumetric pipette was necessary to acquire consistent results for our salicylic acid content.
Test tube 4: basically nothing happened, a few bubbles were formed. 5 minutes later.... Test tube 1: sky blue colored, anti acid table didn't dissolve all the way. Foam dissipated slightly Test tube 2:sky blue colored, foam dissipated a little. All the antacid tablet was dissolved.
Lab 8: Chromatographic Analysis of Analgesic Drugs Written by Gurleen Bhangoo Robinjot Kaur CHEM 3301-02 Professor Jeffery Crisman 21 March 2023 Abstract: Chromatography is an analytical method that is used to separate a mixture of chemical compounds into their individual components, allowing the individual components to be thoroughly analyzed. In this experiment, thin-layer chromatography (TLC) is performed to identify an unknown drug, and then column chromatography is used to separate out the components of the drug. The given unknown will contain one of the following drugs: Advil, Anacin, Aspirin, BC Powder, Excedrin, Excedrin Tension Headache, or Tylenol, where each drug will consist of a mixture of 1-3 compounds. The presence of caffeine
3mL of strong smelling, clear colorless acetic anhydride liquid was then measured in a 10mL graduated cylinder in the fume hood, and poured into the Erlenmeyer flask. The flask was then gently swirled while 5 drops of 85% phosphoric acid was added to the flask. During this time, the solution in the flask was whitish and cloudy. Phosphoric acid was used in the synthesis to become a source of H+ ions that would catalyze the reaction. Phosphoric acid is a liquid that doesn 't contain much water, since water will cause side reactions and reduce the yield of acetylsalicylic acid.
This clearly indicated addition of H2O molecule to the drug. As the Application of nitrogen rule and proposed the presence of even nitrogen ie, C12H15NO4 (Theoretical mass 237.10) as the most probable molecular formula. Degradation product 02 is generated from the drug by simple amide hydrolysis in basic condition. Since Degradation product 02 was formed in basic, It was observed that, AN undergoes base hydrolysis. Degradation study of Product 01 using Aqueous 1N NaOH solution .The
In addition, phenolphthalein was added as an indicator. The aliquots were titrated against sodium hydroxide (NaOH) solution until end point was reached, after which volume of NaOH consumed was recorded. The value of the rate constant, k, obtained was 0.0002 s-1. The experiment was then repeated with 40/60 V/V isopropanol/water mixture and a larger value of k = 0.0007 s-1 was obtained. We concluded that the rate of hydrolysis of (CH3)3CCl is directly proportional to water content in the solvent mixture.
The hydrolysis formed salicylic concentration which was mixed with iron(III) solution to form a purple complex. This was then use to study under the UV/Visible absorption spectroscopy which gave absorbance values recorded at 525nm to determine the concentration of salicylic acid using the Beer Lambert’s Law and later corrected to find the actual concentrations. The concentrations of aspirin at various intervals was found from salicylic concentrations. Upon plotting a graph of ln(aspirin) vs time, it produced a linear equation from which the gradient gave the rate constant of 0.0083min-1 and the overall shape of the graph concluding this reaction to be pseudo first order with respect to the concentration of aspirin with the deviations and improvements as
The main objective of this experiment was the formation of phenacetin from the synthesis of acetaminophen. This was done through a chemical reaction known as the Williamson ether synthesis using techniques of refluxing, vacuum filtration and recrystallization incorporating a mixed solvent system. A further objective of this experiment was to study the formation of the product (phenacetin). Such validation was completed by using techniques for determining the melting point, calculating percent yield, and IR (infrared spectroscopy) of the resultant product.
Introduction Due to its affordability and effectiveness, acetylsalicylic acid, or Aspirin, is a widely popular over-the-counter medication2. Part of a medication class called ‘NSAID’s (non-steroid anti-inflammatory drugs), aspirin is commonly used in the treatment of simple inflammatory ailments such as headaches and low-grade fevers2. The synthesis of aspirin is relatively simple. The two reactants are acetic anhydride and salicylic acid and the products are acetylsalicylic acid and acetic acid1.
Filtered the solution through 0.45 µm nylon filter Buffer having pH 3.70 used as Mobile phase A and mixture of methanol, acetonitrile and tetrahydrofuran (50: 50: 2 v/v/v) were used as Mobile phase B. Diluent: Prepared a mixture of buffer and methanol (80: 20 v/v). Placebo preparation (Placebo I): Weighed accurately and transferred 255 mg of placebo to a 100 mL volumetric flask. Add 40 mL of methanol and sonicated for 10 mins and add about 30 mL of diluent and again sonicate for 15 mins. Allow to equilibrate at room temperature (RT) and dilute to volume with diluent.
The reactions between acids and bases of solutions are extremely important in a number of different contexts such as industrial, environmental, and biological. Acid reflux is common in many people and it causes heartburn; Antacids help temporarily alleviate this. This investigation helps
Lecturer Date Introduction Theoretical Background Procedure The procedure was segmented into two categories, the reaction set up and the crude product isolation. Reaction set up The magnetic stirrer was prepared through placing it in the fume cupboard. 1 mmol of L-Phenylalanine was placed and weighed in a 5 mL conical vial.
Aspirin is synthesized through three different steps, the synthesis of the aspirin, the isolation and the purification and finally the purity estimation of the final product. It involves the reaction of acetic anhydride and salicylic acid in the presence of phosphoric acid = H3PO4. After the aspirin is synthesised it then mist be isolated form the reaction solution and purified. This procedure is a possible experiment to execute at a