Duchenne Muscular Dystrophy Research Paper
Duchenne Muscular Dystrophy Introduction Duchenne Muscular Dystrophy is a dangerous and rare disorder. It is transferred through family generations because it is a genetic disease. Duchenne Muscular Dystrophy is referred to by many names including DMD, Duchenne Syndrome, and Pseudohypertrophy. DMD is when the body cannot make dystrophin so it results in muscle weakness. Mode of Inheritance Duchenne Muscular Dystrophy is a X-linked recessive disorder and that is why DMD is more common in males. Women can only be a carrier of the disease, but it is rare for women to actually experience some of the symptoms. Women have two X-chromosomes so that is why they will not have the disease. They have one defected gene and one normal. Their normal …show more content…
Cardiomyopathy can occur from the lack of dystrophin on the heart muscles. Cardiomyopathy makes it difficult for the patient to breathe. The heart becomes weak and swollen. It is not able to pump enough blood throughout the body, which will cause life-threatening results. This type of muscular dystrophy comes along with not only physical issues but psychological as well. Duchenne Muscular Dystrophy also can cause mental issues associated with reading, writing, and math. This is not as common as the heart problems, but still can show up as being related to Duchenne Muscular Dystrophy. Many of the children with DMD experience physiological problems because they are different and can’t be as independent or active as other kids their age. This can cause depression. Duchenne Muscular Dystrophy is a disorder that is both mentally and physically challenging. Duchenne Syndrome is caused by the mutation of a gene on the X-chromosome. A muscle protein, dystrophin, is affected by this mutation. The damaged gene cannot make enough dystrophin to work right, so it will result in DMD. Dystrophin is a protein that is associated with muscles in the heart, bones, and some in the nerve
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1203 Words | 5 PagesThe results fitted nicely with the author’s hypothesis, showing PGC-1α gene transfer was able to control and enhance dystrophin-deficient muscle functioning. Despite successful results, the authors have noted contradicting findings such as increased inflammation in the treated limbs. Little explanation was given as to why and whether it could affect the muscle in the long run, so more elaboration is needed. Overall, the study was well-designed with results to support the hypothesis of this potential treatment for DMD to mitigate symptoms and restore muscle
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