Cald1 Unit 1 Research Paper

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Caldesmon 1 is a gene that is located on Chromosome 7: 134.74 – 134.97 Mb which encodes a calmodulin binding protein. (15) The products of CALD1 such as Calmodulin- and actin-binding proteins play an essential role in the regulation of smooth muscle and nonmuscle contraction. (16) CALD1 inhibits ATPase activity of myosin in smooth muscle like calponin. Caldesmon (CaD) is an actin-linked regulatory protein found in smooth muscle and non-muscle cells. It binds and stabilizes actin filaments, as well as regulating actin-myosin interaction in a calcium (Ca2+)/calmodulin (CaM)- and/or phosphorylation-dependent manner.(17) The domain of this protein includes binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. As

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