Gemfibrozil Lab Report
INTRODUCTION:
Gemfibrozil[1-3], 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (Fig.1), is a fibric acid anti-lipemic agent used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).it increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so by activating Peroxisome proliferator-activated receptor-alpha (PPARα) 'transcription factor ligand', a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides
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It is available in local pharmacies as capsules for oral administration [Each capsule containing 300mg of gemfibrozil.
Several HPLC methods in various body fluids[4-10] and one UV-spectrophotometric method[11] in pharmaceutical formulations have been reported and published for gemfibrozil assay. This fact prompted the author to develop a simple, inexpensive UV-spectrophotometric method for the determination of gemfibrozil in pure and in dosage forms. The present research paper describes the development and validation of the UV-spectrophotometric method for the assay of gemfibrozil in pure and from its formulation (tablets) as per ICH validation guidelines using double distilled water as
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