Disseminated Intravascular Coagulation (DIC) Disseminated intravascular coagulation (DIC) is a case of uncontrolled activation of proteins that are involved in the clotting process such as thrombin, fibrinolytic proteins, platelets, and coagulation factors. DIC occurs due to inflammation, trauma, infection, and shock. The presence of mucocutaneous bleeding is an evidence of DIC. Disseminated intravascular coagulation has acute and chronic phases. In acute phase, a patient will have severe symptoms while in chronic phase a patient may suffer from inflammation of blood vessels or adenocarcinoma.
Symptoms • Yellowing of the skin (jaundice) due to the accumulation of bilirubin in the blood • Fatigue • Weakness • Loss of appetite • Itching • Easy bruising from decreased production of blood clotting factors by the diseased liver Causes • Alcohol • Viral Hepatitis B & c Effects •
Herpes Zoster(shingles) also known as the reactivation of the Varicella-Zoster virus. Varicella-Zoster virus is another word for the chickenpox. Chickenpox is mainly describe as a childhood infectious disease. If you have developed chickenpox there is a chance you can develop Herpes Zoster. This disease is often presented in elderly because there cellular Immunity is reduced.
Each element has its own toxicology profile and how these elements are useful to the human system (Klaassen, 2001). Dental amalgams deteriorate due to a number of causes, namely; mastication, vigorous teeth brushing, oral temperature increase and abrasion. When the dental amalgam is damaged it tends to release a mercury vapour or little pieces of amalgam which are ingested into the system with beverages or food (SCENHIR, 2007; Roberson et al., 2006; Huggins, 1992). The amount of damage dental amalgams can produced is based on the size, sensitivity of the patient to one of the elements in the amalgam, composition of the amalgam, the age of the amalgam and the surface area covered by the amalgam (Weiner et al.,
Matrix metalloproteinases (MMPs), assume a key part in periodontal disease. Periodontal disease is an aggravation of the gums which takes place after gingivitis when left untreated. Abundance microorganisms make pockets in the gums that harm the supporting structure of the teeth. MMPs contain enzymatic movement which is managed by tissue inhibiting matrix metalloproteinases (TIMPs). These proteins aid tissue redesigning and furthermore debase the extracellular matrix found inside the gums and result in the negative harm of them too.
Whereas, some drugs simultaneously modify both the apoprotein and the prosthetic heme group of CYP enzymes. For example, spironolactone (antihypertensive drug) is irreversible inhibitor of the CYP2C and CYP3A subfamilies (Juinn et. al., 1998). 1. Heme Alkylation: Drugs containing terminal double-bond (olefins) or triple-bond (acetylenes) can oxidized by CYPs to potent radical intermediates, which alkylate the prosthetic heme group and inactivate the enzyme.
When that happens it can actually deposit into our female predominant tissues or our gynecological tissues and start causing growths to happen. What we need to start doing is avoiding our exposure to those chemical and start flushing them out of our system.” The products that most people use to fulfill their idea of beauty cause health problems. This doesn’t mean to throw out all of your makeup, but what it does mean is to check all of your makeup and see what they rate on the toxic scale and if they are a 4 or about they should be thrown out. The doctor also says you should check your toothpaste or other materials that have chemicals in
DDT was widely used after World War 2 for pest control. It is a potent neurotoxin; therefore it damages the nervous system. It can cause impaired motor function and impaired cognition. It has also been linked to numerous other conditions such as infertility and cancer. What are the health effects of pesticides on humans?
Thousands of babies had deformities because tests on hamsters and rats showed the pill to be effective. Additionally, “Animal tests on the arthritis drug Vioxx showed that it had a protective effect on the hearts of mice, yet the drug went on to cause more than 25,000 heart attacks and sudden cardiac deaths before being pulled from the market” (Vioxx). Animal testing is extremely misleading in the medical field. Scientists attempt to link the results of testing drugs on animals to its effectiveness on humans. There is an extreme lack of results that comes from animal testing, furthering that scientists should use methods that do not involve animals when testing new drugs and other medical
Anemia is mainly causes by iron deficiency. If not treated it leads on to deficiencies of thyroid hormones, folate, vitamin B12 and other important hormones in the body. Other causes may include chronic diseases like megaloblastic anemia. On the other hand when the values are above normal, it maybe be as a consequence of dehydration in which the value should be raised. • Neutropenia White blood cells include neutrophils, neutrophils function and immune system protector that combat against diseases and infections.
So what exactly is rhabdomyolysis? It is an imbalance in the muscle that happens when the muscle tissue of an affected area breaks down quickly, which can release its toxins into your blood stream. This can be caused by a hard hit to a muscle, causing muscle injury, as well as from the use of certain narcotics and even severe dehydration (Cervellin 2010). As learned in the course muscles are composed of sarcolemma which is the membrane that is composed of many Na+, K+ and Na+, CA+ channels that when a muscle is injured , stop functioning
Lysosomes digest the toxins so they can be safely eliminated by the cell. Peroxisomes contain oxidases and catalases that detoxify substances like alcohol and neutralize free radicals. The smooth endoplasmic reticulum (ER) also contains enzymes that detoxify certain drugs (such as alcohol). 3. Mrs. Fender’s jaundice is caused by the accumulation of bilirubin in her blood and tissues.
This includes increased concentrations of heavy metals such as Mercury (Hg) and Lead (Pb) found in the liver tissue and/or chemical toxins such as man-made Polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (e.g. DDTs) and these are found in the blubber tissue of cetaceans.(Pierce et al. 2008; Jepson et al. 1999): To investigate the high proportion of Harbour porpoises dying from infectious disease, chemical sampling was undertaken in the liver/blubber tissue of the strandings to research the effects of PCBs earlier mentioned as well as heavy metals like Mercury (Hb). The amounts of these chemicals were examined in those individuals killed by infectious disease and those that were healthy and died from physical trauma.
Homogentisic acid is produced in the body from the improper breakdown of tyrosine and phenylalanine in the body. The excess homogentisic acid accumulates in the blood and also in the connective tissues such as cartilage and this happens in a great amount around the joints. The accumulation of blood leads to development of ochronosis, arthritis, heart issues discoloration of the skin in certain areas and many more complications that are seen in patients with AKU. In basis terms AKU is a disorder that results from the improper breakdown of tyrosine and phenylalanine because there is a deficiency of the enzyme HGAO. The gene that encodes the HGD enzyme was cloned in 1996 that is when they opened the era of molecular genetics of AKU.
The liver produces hormones and proteins, in addition to cholesterol and affects the way the body grows and heals. It also converts existing amino acids into proteins and creates new amino acids. And it is these proteins that are the building blocks of the hormones,