Schiff Base Synthesis

Abstract – In this Research paper a new Schiff base ligands like HMAPPTH (p-Toulic hydrazone and 2-hydroxy, 4-methoxy acetophenone Schiff base), and RAPPTH (p-Toulic hydrazone and Resacetophone Schiff base) and its vanadium metal complexes have been synthesized and characterized by various physio chemical techniques & methods like FT-IR, H1-NMR, UV-Visible, ESR, VSM, Molar conductance, XRD and micro analytical data and biological activity studies.

Key words - Schiff base, antibacterial activity, Vanadium (IV), HMAPPTH and RAPPTH.

I.INTRODUCTION

Schiff bases are very important today because its play an important role in chemistry and all interdisciplinary subjects. Schiff base and their metal complexes have been found to posses important

The whole mixture was transferred into 250 ml round bottom flask. The mixture was refluxed about 2 hours on water bath. When the reaction mixture was allowed to cool yellow crystals were obtained. The compound was recrystalized from ethanol. The % of yield was 78% and melting point of the compound was 190 - 192 0C.

Scheme 2: Synthesis of p-toluic hydrazide and 2-hydroxy-4 mehoxy Acetophenone Schiff base

B. Synthesis of RAPPTH & HMAPPTH - V (IV) Schiff base Metal Complexes:
The reagent p-Toluic hydrazide and Resacetophenone (2,4 Dihydroxyacetophenone) Schiff base was dissolved in 40ml of 50% methanol and V (IV) metal ions dissolved in 20ml of distilled water, this compounds mixture was stirred for 6 hours in the presence of sodium acetate. Orange red color metal complex (RAPPTH) was formed with good yield. This product washed several times with hot water and cold methanol to free from un reacted metal slats and ligand respectively and finally with ether and dried in vacuo over calcium chloride

The thermo analytical data is summarized in Table.1. The thermal decomposition proceeds in three stages. The RAPPTH & HMAPPTH-V (IV) metal complexes are thermally stable up to 66 and 720C respectively. In the first stage loss of two water molecules occur in the temperature range 60-130oc and 72-110oC respectively for RAPPTH & HMAPPTH (IV) complexes by decomposition corresponds to endothermic dehydration. The intermediates are stable up to 230 and 2100c.The second decomposition with exothermic peak by the loss of ligand moiety occurs in the temperature range 230-583oc and 210-550oC. The solid residues above 600, and 5500C were recognized as vanadium metal oxides respectively for RAPPTH & HMAPPTH-V (IV). The final products are metal oxides in all the metal complexes.The molar conductance data of complexes which was carried out in DMF at10-3. The molar conductance values are 6.00 and 6.48 ohm-1 cm2 mol-1 respectively for RAPPTH & HMAPPTH-V (IV).These values suggest non-electrolytic nature of the present