Essay On Protein Folding

Protein folding in the cell is crucial for their function and existence of life. The ability of macro-molecules to assemble to three dimensional fold either with or without the assistance of cellular component has characteristic importance for a living system. It is important to understand the basis of folding mechanisms of proteins. Resolving protein folding mechanism and how folding processes are regulated is a challenging in the modern science. Protein needs to fold to their native or functional state is the most fundamental ansd common example of biological self-assembly. This complex process provides perceptional knowledge towards the evolutionary selection for functional advantage inside the cell. The protein folding has known to regulate

Native states of proteins is the most stable under physiological conditions. The random scan for the search of particular state of the protein take quantitatively very longer time. However, it is well established that the folding of the proteins are rapid reactions which happens from few seconds to longer time. All proteins does not necessarily follow the same path for folding, they follow various steps or stages of protein folding which leads to various intermediate states. The native or functionally active state of proteins are formed inherent intermediate conformation. The temporal contacts of these intermediate structures enables formation of active protein. Protein folding is a self-organization or assisted folding by various components folding machinery which aids in lowering the energy barrier to attain the natively folded structure. The energy landscape theory of protein folding suggests statistical description of the free energies of different molecular configurations of the proteins. Eventually the energy landscape of a folding protein follows a partially rough funnel and coarse nature of the funnel depicts intermediate conformations or traps of the proteins which attains their local