Synthesis of 4H-Pyrido-[1,2]-pyrimidine derivatives by using sulphamic acid as catalyst. Sreelatha Vanjivaka a , Kakarla Ramana Kumar b* , Jyothi Vantikommu a , Suryanarayana Murthy Goparaju c , Sadanandam Palle a* a Centre for Chemical Scciences & Technology, IST, JNTUH, Hyderabad-500085, India. b Department of Chemistry, CMR Institute of Technology, Secunderabad- 501401, India c Department of Chemistry, CMR Technical Campus, Kandlakoya, Medchal, Hyderabad- 501401. India ? Corresponding author: Fax: +91-40-23058729; E-mail: sadanandampalle@gmail.com Abstract: Synthesised three component, one pot synthesis of 4H-Pyrido-[1, 2]-pyrimidine derivatives by condensation of 2-minopyrimidines, aldehydes and ketones in the …show more content…
Chem. 2002, 67, 2619?2631. 4. Wu, Y.-J.; He, H.; Hu, S.; Huang, Y.; Scola, P. M.; Grant-Young, K.; Bertekap, R. L.; Wu, D.; Gao, Q.; Li, Y.; Klakouski, C.; Westphal, R. S. Identification of a potent and selective 5- HT6 antagonist: Onestep synthesis of (E)-3-(benzenesulfonyl)-2-(methylsulfanyl)pyrido-[1,2- a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis- (methylsulfanyl)acrylonitrile. J. Med. Chem. 2003, 46, 4834?4837. 5.Nakayama, K.; Kawato, H.; Watanabe, J.; Ohtsuka, M.; Yoshida, K.-I.; Yokomizo, Y.; Sakamoto, A.; Kuru, N.; Ohta, T.; Hoshino, K.; Yoshida, K.; Ishida, H.; Cho, A.; Palme, M. H.; Zhang, J. Z.; Lee, V. J.; Watkins, W. J. MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model. Bioorg. Med. Chem. Lett. 2004, 14, 475?479. 6. Pryadeina, M. V.; Burgart, Y. V.; Kodess, M. I.; Saloutin, V. I. Synthesis of substituted pyrido[1,2-a]pyrimidines from 2-arylmethylidene- 3-fluoroalkyl-3-oxopropionates. Russ. Chem. Bull. 2005, 54, 2841?2845. 7. C?ebas?ek, P.; Bevk, D.; Pirc, S.; Stanovnik, B.; Svete, J. Parallel synthesis of
Interested Parties: Greg Garcia: a new assistant professor of biochemistry at Western Institute of Technology (West Tech). He is trying to build good relationship with other colleagues in order for him to get a tenure. Hal Edmund: a biochemist from the East Coast who is visiting the West Tech biochemistry department to give a seminar presentation. Carmen Choi: Greg is help Carmen about making her proposal clearer and more persuasive as his senior colleague, Cheryl, request from him.
Cane toads The cane toad, also known as the giant neotropical toad or marine toad, is a large, land based toad which is native to South and Middle America, but has been introduced to various islands throughout Oceania and the Caribbean, as well as northern Australia. Cane toads were introduced to Australia as a solution to cane beetles eating all the sugar cane crops. Body 1
CER Labs 2-3 Figure 1. Friedel-Crafts Acylation. Claim: An acetyl group was efficiently introduced to ferrocene by Friedel-Crafts Acylation (Figure 1).
5-aminotetrazole monohydrate: In a 250 ml round-bottom flask equipped with a condenser for refluxing (90 °C) and a magnetic stirring bar, 5.00 g (5.95 mmol) dicyandiamide (three times crystallized), 7.47 g (11.9 mmol) sodium azide and 11.00 g (17.8 mmol) boric acid and 100 ml of water is added and allowed to reflux for 24 hours, after the completion of the reaction, until the solution pH to about 2 to 3 as hydrochloric acid 37% is added (about 12 ml) Then the reaction mixture was cooled in a refrigerator for 18 hours and the white crystals formed. The mixture was filtered and washed three times with 10 ml of water and and dried in 60 °C for 5 hours and finally 45.8 g of product by it will be obtained. 5-Aminotetrazol monohydrate:
Compound 2 Commonly known as phlorizin. IUPAC name is 1-[2,4-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-phenyl]-3-(4-hydroxyphenyl)propan-1-one was obtained as white to offwhite needle shaped crystals mp 1670C. The UV/Visible spectrum of the compound showed λmax at 226
Bennet, A. S., Bell, A., Tomedi, L., Hulsey, E. G., & Kral, A. H. (2011). Characteristics of an overdose prevention, response, and nalaxone distribution program in Pitsburgh and Alleghany County, Pennsylvania. Journal of Urban Health , 88 (6), 1020-1030. Bennet, Bell, Tomedi, Hulsey, and Kral (2011) describe the experiences of participants in an Overdose Prevention Program (OPP). Their sample consisted of participants of a needle exchange program who volunteered to be part of this study.
In this experiment, hydride reducing agents were used, since hydrides have spare electrons that they can donate to other compounds. Two popular hydride reducing agents, lithium aluminum hydride and sodium borohydride, were considered for this experiment. Since hydride reducing agents were used in this reaction, the reaction would have been extremely sensitive to proton sources, since
Lab Report 5: Acetylsalicylic Acid (Aspirin) Synthesis Name: Divya Mehta Student #: 139006548 Date Conducted: November 19th 2014 Date Submitted: November 26th 2014 Partner’s Name: Kirsten Matthews Lab Section: Wednesday 2:30 L9 IAs Name: Brittany Doerr Procedure: For the procedure, see lab manual (CH110 Lab Manual, Fall 2014) pages 96-98. Wilfrid Laurier University Chemistry Department. Fall 2014. Acetylsalicylic Acid (Aspirin) Synthesis.
In partial synthesis, compounds are created by using large quantities of naturally available resources. This process is both inefficient and time consuming, and it therefore not the most preferable means of developing a compound. Nonetheless, early pioneering German scientists were able to isolate cortisone from yams using partial synthesis (Slater, 2000). The progression from partial to total synthesis was the clear turning point in the development of modern steroids.
The purpose of this experiment is to perform a two step reductive amination using o-vanillin with p-toluidine to synthesize an imine derivative. In this experiment, 0.386 g of o-vanillin and 0.276 g of p-toluidine were mixed into an Erlenmeyer flask. The o-vanillin turned from a green powder to orange layer as it mixed with p-toludine, which was originally a white solid. Ethanol was added as a solvent for this reaction. Sodium borohydride was added in slow portion as the reducing agent, dissolving the precipitate into a yellowish lime solution.
In our initial experiments, a 19% yield of 3,4-dicarbonyl substituted furan 3a was obtained when α,β-unsaturated carbonyl (1a) and 1,3 diketone (2b) were employed for the reaction (Table 1, entry 1) in a 1:2 molar ratio in the presence of 10mg of CuO-NPs in EtOH at room temperature without any oxidizing agent. When molar ratio of the reactants 1a and 2b were increased to 1:3, an improvement in the yield to 28% was observed (Table 1, entry 2) and molar ratio 1:5 gives the highest yield in the same reaction conditions 38% (Table 1, entry 3). The polar solvent such as DMF, DMSO, H2O, Xylene also gave the desired products but in low yield, while no reactions occurred in acetonitrile, toluene (Table 1, entries 4−9).When we employed a mixture of solvent EtOH: H2O (4:1) slight increase of yield 46% was obtained (Table 1, entry 10), increasing the mixture of solvent ratio to 2:1give the yield 51% (Table 1, entry 11) and solvent ratio 1:1 give the highest yield 60% (Table 1, entry 12).
Next, the oxygen is protonated from the 3-nitrobenzaldehyde, which is then followed by an elimination reaction where this acts as a leaving group. The product is the trans-alkene present in the product. After the reaction was completed, purification of the product was conducted using semi-microscale recrystallization.
It is understood the mechanism is acid-catalyzed where protons coordinate with the carbonyl oxygen to make the carbonyl carbon more electropositive for nucleophilic attack (Scheme 1). In the experimental procedure all reactants were added together, this is inefficient as the protons can coordinate with either trans-cinnamic acid or methanol. Coordination with methanol is unnecessary as it reduces its nucleophilicity and makes less protons available to coordinate with the carboxylic acid. To improve
The purpose of this lab is to use the Diels-Alder reaction to combine anthracene and maleic anhydride. Named after its two founders the Diels-Alder reaction is the addition of a conjugated diene (electron rich compound) with a dienophile (electron poor compound). (1) These compounds will be combined using [4+2] cycloaddition, where the numbers 4 and 2 come from the number of π electrons that are used in each compound to synthesize the product. (2) This experiment comes at the cost of losing two π bonds to form two new sigma (σ) bonds in the cyclic compound. (2)