Epilepsy Research Paper

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CHAPTER III
METHODOLOGY
This study was conducted to assess the adherence pattern to antiepileptic regimen among patients with epilepsy and to identify the socio demographic, clinical and patient related factors associated with the adherence pattern to antiepileptic regimen.
Research Design Cross sectional survey design was adopted for the study.
Setting of the Study The study was conducted in Jawaharlal Institute of Post graduate medical Education and Research (JIPMER) a tertiary care hospital, an Institute of National Importance under the Ministry of Health and Family Welfare, Government of India. JIPMER is a tertiary care hospital with a daily average number of out-patient attendance of 6247 and total number of yearly patient admission
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The clinical data sheet included duration of epilepsy, type of epilepsy, frequency of seizure, co-morbidity, complexity of treatment, medication frequency, side-effects, and family history of epilepsy.
• Section C: Assessment of the Patient related factors such as lifestyle, social support and patient-prescriber relationship by using Rating Scale.
• Section D: Assessment of the Behavioural factors such as knowledge, belief and attitude by using Questionnaire consisting of 30 questions.

Validity and Reliability: The questionnaire to assess the determinants of antiepileptic medication adherence was developed by the investigator from literature search. The tool and was validated by 4 experts, two medical experts from Neuromedicine department and two nursing experts. According to the suggestions of the experts, modifications were done on the
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Pre testing of the tools were done in 20 epilepsy patients and found that the languages used in the tools were clear, simple and unambiguous. They were able to understand and respond to the items in the tools. The reliability of the questionnaire was 0.80 and it was calculated using test-retest method.

Data collection procedure
• The study was approved by JIPMER Scientific Advisory Committee and Institute Ethics Committee.
• Patients who fulfilled the inclusion criteria were selected through convenience sampling technique. Once in a week (every Monday), 12-15 subjects per day were interviewed.
• Structured interview and record review were carried out after explaining purpose of the study and getting informed consent from the participant.
• Good interpersonal relationship was maintained with the patients.
• It was a one-time data collection requiring 30-40 minutes per patient.
Data Analysis Both descriptive and inferential statistics were used for analysis of data. Descriptive statistics (mean, standard deviation, frequency and percentages) were used to describe the clinical and demographic variables of study participants. The determinants of medication adherence were analyzed using Chi-Square test and Independent Student T Test.
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