Write An Essay On Paget's Disease

DEFINITION Paget disease is defined as a disease that involves destruction of abnormal bone. This disease occur when overactivity of osteoclastic and also followed by compensatory of osteoblastic activity that lead to a struture of the bone ( woven bone ). Usually affected skull, pelvis, femur, tibia, and lumbar spine ( http://emedicine.medscape.com/article/334607-overview ) ( http://photos1.blogger.com/blogger/6305/3126/320/paget.jpg ) DISEASE CLASSIFICATION

Variolation was a way to eliminate smallpox but it still led to deaths in about one to two percent of individuals. The smallpox infection was eventually eradicated through vaccination developed by Edward Jenner, and through many other public health services such as surveillance, prevention, cooperation, and health programs. The eradication of smallpox was significant in the world at the time but there are still many problems that have caused controversy today. One of those problems includes the remaining strains of smallpox that is located at the CDC in Atlanta and another in Russia. Throughout history, the infection dilemma has gone from being spread through sneezing and coughing, and now it may be able to spread through an attack.

Typically, it happens when the bone was subjected to impact of more force or pressure than it can withstand. Commonly, broken bone can happen in childhood and mature and late adulthood. Children’s bones are still forming yet in mature and late adulthood, elderly becomes more likely to trip and fall. There are many types of fractures, but the major classes are simple fracture and compound fracture [1]. These fractures can be transverse

Introduction Kyphosis is a spinal disorder involving an excessive outward curve that causes an abnormal rounding of the upper back. It occurs when the spinal bones (vertebrae) in the upper back (thoracic spine) become wedge-shaped and cause deformity. Kyphosis is sometimes called dowager's hump, hunchback, or roundback. It is most common among elderly people, but can happen at any age. There are four main types of kyphosis: Postural kyphosis.

The three key terms every orthopedic surgeon should know are osteoarthritis, osteoporosis and excess purine. In most cases, patients tend to have a slip disc causing osteoarthritis. Osteoarthritis is a degeneration of joint cartilage and the underlying bone. It is most common for middle-aged people and seniors. It causes pain and stiffness, especially in the hip, knee and thumb joint.

Losing bone mass can cause brittle bones and osteoporosis which again, is a disease in which brittle bones take place and tend to break a lot. “ Osteoporosis is a serial killer. It affects one in three women and one in 12 men - and kills more women than all gynecological cancers put together. Bones get progressively more brittle until they snap and when they do, it's bad news” (“Health, the Dangers of Osteoporosis”) “Broken bones are the only danger.

What are the symptoms of peripheral artery disease? Snippet: Peripheral arterial disease (PAD) is a condition, in which a build-up of fatty deposits (atherosclerosis) in the arteries leads to the narrowing of the peripheral arteries and reduce blood flow to the legs, stomach, arms, and head. According to statistics, both men and women are affected equally by this condition. However, the prevalence increases as one age.

Here are the common causes why people develop extra bone over bone. 1. What Causes Bone Spurs? • Osteoarthritis Osteoarthritis is a degenerative bone condition that affects various joints of the body, including the spine. It is a common cause of low back pain, especially in older patients, that causes stiffness and pain.

INTRODUCTION Psoriasis is an ancient and universal inflammatory, autoimmune, polygenic (Shai et al, 2002) and chronic skin disease that is characterised by scaly, sharply demarcated red, dry patches and indurated plaques. Patches most often occur on the elbows, knees and lower back. They may also be seen on the upper pelvic bone area, bottom of the feet, calves and thighs, genital areas and Palms of the hands. Psoriasis can develop at any age, but a bimodal distribution of the age of onset is characteristic.

It is also possible to appear stiff joints in the morning. Arthritis can be migratory or episodic. These symptoms usually occur early in the disease and its evolution. dermatological symptoms La, although not the most common, known injury is called " erythema butterfly wings ," which consists of a flushing and skin rash on the face, cheeks and nose. These symptoms occur in 80 percent of patients and many worsen with sun exposure.

The symptoms of myeloma are mostly pain but the ribs and spine are the most effected areas in the body causing chest wall or back pain. If the myeloma is advanced can cause bone degeneration which can press on the nerves causing little feeling, burning sensation and paralysis. It can cause high levels of calcium destroying the bones at a fast rate. The other complications cryoglobulinemia this rare condition produce a protein that precipitates, when it is exposed to cold temperatures. Amyloidosis occurs mostly in people whose myeloma has the light chain components of immunoglobulins to form a sticky protein called amyloid, impairs the function of whichever organ it is in.

It is caused from a postzygotic missense mutation in gene coding for one of the subunits. Some symptoms of fibrous dysplasia include: Uneven growth of bones, pain, brittle bones, and bone deformity. A few

Because it has so many different symptoms, it is extremely difficult for doctors to recognize. When a patient first gets a tick bite, they usually contract a bull’s eye rash which “starts as a small red spot that expands over a period of days or weeks, forming a circular, triangular, or oval-shaped rash” (“Lyme Disease Overview”). However, this rash, scientifically called erythema migrans, only appears in seventy to eighty percent of Lyme disease victims, making the disease even harder to diagnose. Early symptoms of Lyme disease include flu-like symptoms such as fevers and chills, joint pain, and muscle aches. After a couple months, victims of Lyme disease may develop many symptoms such as facial paralysis, poor memory, weak limbs, heart problems, and swollen joints.

As of 2013, the number of people with MS was estimated to be over 2.3 million worldwide. ( atlas 2013) Most of the non-traumatic disabilities in young adults are caused by MS [1]. It is considered that an interaction of genetic factors, environmental predisposition, and abnormal immune responses can be the chief causes of MS, But the exact etiology of MS is still in question [2]. MS has been greatly studied within the recent years, but a great number of clinical challenges still remain in regard to diagnosis, prognosis, and treatment.[6]

Fibrodysplasia ossificans progressiva is one of the rarest and most disabling disease known to mankind. The disease progression is caused when connective tissue such as; muscle, tendons, or ligaments are slowly replaced by bone. Eventually, the additional bone formation outside the skeleton will constrict movement and imprison the body. The literature on fibrodysplasia ossificans progressiva is sparse, which could account for the extremely high rate of misdiagnoses of the disorder.