Spherical Crystallisation Research Paper

Now-a-days direct tabletting technique is gaining more importance in Pharmaceutical manufacturing because it save money and time for tabletting but Good flowability and compressibility is prerequisite for drug to be prepared by direct compression. There are several techniques available to impart desired compressibility to drug but the Spherical crystallization technique is the most promising one in which the drug crystals are modified using different solvents to directly compressible spherical agglomerates. Spherical agglomeration is particle engineering technique which involves the transformation of fine crystals into spherical shape which in turn enhances the powder properties such as particle size, shape, flow properties, solubility and bioavailability of pharmaceutical drug substances. The spherical crystallization further developed use with hydrophilic polymers to enhance dissolution

Hence spherical crystallisation process can be defined as:
“A novel particle engineering technique by which crystallization and agglomeration can be carried out simultaneously in one step to transform crystals directly into compacted spherical form” OR, “An agglomeration process that transforms crystalline drug directly into compact spherical forms for improving the flowability, solubility and compactability”
Agglomeration is a particles technology process which involves the aggregation of smaller crystals to form bigger particles. The bigger particles are important for properties such as filtration, drying, washing etc. and the end properties such as dissolution, product formation and