Coagulation Essays

Coagulation system is a process to prevent blood loss from the body. Hemostasis process occurred in three phases, vascular platelet phase, activation of the coagulation cascade and the activation of a control mechanism. Mostly, the system is triggered by a damaged blood vessel. After vascular injury, rapid vasoconstriction will serve to reduce blood flow. At the same time, von Willebrand factor (vWf) will act as a bridge between endothelial collagen and platelet surface receptor glycoprotein Ib (GPIb)

Disseminated Intravascular Coagulation (DIC) Disseminated intravascular coagulation (DIC) is a case of uncontrolled activation of proteins that are involved in the clotting process such as thrombin, fibrinolytic proteins, platelets, and coagulation factors. DIC occurs due to inflammation, trauma, infection, and shock. The presence of mucocutaneous bleeding is an evidence of DIC. Disseminated intravascular coagulation has acute and chronic phases. In acute phase, a patient will have severe symptoms

avoid IM inj, use soft tooth-brush, do not floss, use electronic razor until coagulating defects corrected. To report symptoms of bleeding. Not to use OTC medications unless approved by prescriber. The importance of frequent lab tests to monitor coagulation factors. 3.2. Drug Study (II) Hepatitis B vaccine (Karc, 2006) Generic Name- Hepatitis B vaccine Trade Name- Engerix-B, Recombivax HB Therapeutic Actions Provide inactivated human hepatitis B surface antigen particles to stimulate active immunity

disorder which causes a bleeding tendency, mainly into joint spaces. This is due to the inadequacy of clotting, (L.A.Valentino et al 2012). This disease is developed from a mutation of the gene F8 which contains information on how to make the protein, coagulation factor VIII in the plasma which contributes to blood clotting. Therefore the disruption of this process leads to prolonged bleeding, (Konkle BA, Josephson NC and Nakaya Fletcher S, 2000). The key symptom of Haemophilia A is joint and muscle bleeding

leading to the activation of coagulation extensively (Dressler, 2009, p.174). A great amount of thrombin develops in the circulation that exhausts the natural ability of the body to produce anticoagulants such as anti-thrombin, protein C and protein S (McKane, 2010, p.1051). As a result, fibrin clots interrupt blood flow through tissues and organs leading to hypoperfusion, ischemia, infarction and necrosis (McKane, 2010, p. 1052). Due to a high consumption of pro-coagulation factors and platelets during

common pathways of the clotting cascade and assesses factors I (fibrinogen), II (prothrombin), V, VIII, IX, X, XI, and XII”(Hammami, 2013, p. 1). When performed with prothrombin time (PT) test, it evaluates the extrinsic and common pathways of the coagulation cascade. The PT, along with the INR is used to assess the therapeutic of oral anticoagulants and can determine if the patient is at an increased risk of bleeding (if above range) or an increased risk of clotting (if below

being targeted by complement. The coagulation phase begins about thirty seconds after the initial injury. It involves a complex sequence of events that ultimately leads to the activation of fibrin form fibrinogen. There are two separate clotting pathways, the intrinsic and the extrinsic. These eventually join together to form the common pathway. The adsorption of the components of the contact system facilitates the activation of the intrinsic pathway of coagulation. This results in the formation of

Nursing, a job that not only helps people, but touches their lives. I have wanted to become a nurse since I was 5 years old. Children always say what they want to be when they are little, but eventually change their minds. It has been 11 years since I decided my career, and I still have not changed my mind. I was lured into the nursing field because of the care nurses have towards their patients, it is more than a job. Also, everyday is a new challenge for a nurse, never knowing what will come in

Hemophilia and its impact on our society 1Hemophilia is a rare inherited bleeding disorder in which the blood does not clot normally. Hemophiliacs do not bleed more extensively or even more quickly than other people, but they do bleed for a longer time after an injury or a surgery. Bleeding may oc-cur internally especially in the knees, ankles, elbows and into tissues and muscles. If it is left untreated then the internal bleeding into joints and muscles will cause agonizing pain and severe crippling

Pathophysiology of Hematuria Throughout the process of filtration by the kidneys, along with the help of the ureters, the bladder and urethral to expel urine from the body, there are many possibilities that abnormalities can develop that could compromise the healthy characteristics of the filtration process. Hematuria, for example, is the irregular presence of red blood cells in the urine due to dissected variations of trauma in the urinary tract. There are two types of causes of hematuria, the

Hemophilia, Hemophilia is a rare genetic disorder, which prevents blood from clotting. Hemophilia could occur in both a female and male, but most commonly in males (Learning about Hemophilia 2011). Classic Hemophilia affects approximately every ten thousand person in the population (Elaine Sergis 1972). There are two common Hemophilia disorders, which are Hemophilia A and Hemophilia B. Hemophilia A is the most common one, it is caused by having low levels of clotting factor VIII (Mayo Clinic Staff

3. Results and discussion 3.1. Coagulation performance of CB[8] for HA removal The effect of the CB[8] dosage on HA coagulation in the absence of added salts in the synthetic water (fresh water) was investigated at pH 7.5. When the CB[8] dosage was less than 0.2 mmol/L, flocculation was not observed during coagulation. The HA removal efficiency was less than 50% (Fig. 1a). When the CB[8] dosage was higher than 0.2 mmol/L, considerable amounts of flocs formed. At a CB[8] dosage of 0.3 mmol/L, the

Hemophilia - the hereditary lack of a blood clotting factor typically caused by a recessive X-linked genetic mutation - has been at the forefront of public attention for centuries due in part to its seemingly mysterious presentation almost exclusively in males and its prevalence among European and Russian royal dynasties due to inbreeding - but has only been the subject of serious medical study and treatment for the past two centuries. “Before the modern era, there was some recognition of the experience

Haemophilia A is an X-linked recessive disorder and is caused by an inherited genetic mutation that is a permanent alternation in the DNA sequence which makes up a gene. This means that some of the body processes will not work in a normal way. The DNA molecule is packaged into a thread – like structure called chromosomes and they are responsible for carrying genetic information in the form of genes. There are two types of sex chromosomes: the X chromosome and the Y chromosome. All humans have a pair

If you have heart failure, you are not alone. Currently, approximately 5.7 million people in the United States live with it. In fact, it is one of the most common reasons why people 65 years of age or older admitted to hospital. The development of heart failure can take years. Heart failure is called congestive heart failure when fluids accumulate in various parts of the body. So if you do not already have, but runs the risk of suffering, you should change your lifestyle now! Symptoms of heart failure

1.2 PROBLEM STATEMENT Care of critically ill patient in the ward is a challenging process especially in the low resource countries. This is due to deficiency/ inadequate specialized or competent skilled personnels and absence of monitoring of patients closely. As the nurses are in constant contact with patients, they are in prime position to identifying problems at an early stage with the use of systematic patient assessment According to the standard of care, systematic assessment framework is

Abigail McWilliams Ms. Castle Pre-AP Biology April 17, 2017 Genetics Research Paper Intro Hemophilia is a sex-linked disorder that causes blood clotting. “A person is lacking proteins called “clotting factors” and the blood doesn’t clot properly as a result. This leads to excessive bleeding.”(Healthline Media) Common symptoms of hemophilia can be bleeding easily; the blood takes a longer time to clot after an injury so you bleed longer and more. Hemophilia can also cause internal bleeding.

blood cells) have a constant interaction, but this interaction increases with elevated cholesterol levels. As the cholesterol levels increase, the monocytes begin to attach onto the endothelium, where they are transformed into macrophages. These macrophages begin to oxidize the LDL and they become toxic to the endothelium which leads to platelet adhesion and aggregation and fibrin deposition. The macrophages begin to ingest the oxidized LDLs transforming them into foam cells, which begins the formation

In Leviticus, a section of the Torah, it says that ailments like skin diseases mean that there is something wrong with that person. The disease was a punishment for a sin that the afflicted person committed. Now this is quite ironic because there are many diseases that affect mainly Jews. These include diseases such as Tay-Sachs disease, Bloom Syndrome, Cystic Fibrosis, Polyglandular Syndrome, and much more. These genetic studies of Jewish genetic diseases would be nowhere without a person that some

process in which floc of metallic hydroxides are generated within the effluent, which to be treated, by electrodissolution of anodes. Compared with flocculation process and chemical coagulation, electrocoagulation (EC) has no of advantages, such as removal of the smallest colloidal particles. Compare to conventional coagulation process, Less amount of sludge is generated during EC process. Excessively addition of coagulants can be avoided by using EC, due to the generation of the coagulants by electro