Glutathione peroxidase Essays

In both ‘Digging’ and ‘Follower’, Heaney creates a tone of respect and admiration for his father and grandfather that permeate all aspects of the poems. He portrays them as being strong, skilful and dedicated; this is achieved through the use of vivid descriptions, structure and careful placement of words with connotations. In ‘Follower’, Heaney portrays his father as skilled and knowledgeable. Throughout out the poem, Heaney uses specialized terms to describe his father’s job, such as ‘shafts’

3. Results The preliminary phytochemical screening of the roots of P. zeylanica showed the presence of sugars, steroids, flavonoids, alkaloids, terpenoids, quinones, phenols, and tannins (Table 11). Alkaloid was seen in ethyl acetate and methanol extracts while terpenoid was noticed only in the chloroform extract. Flavonoid was present only in the methanol extract. HPTLC fingerprinting of ethanol extract of P. zeylanica yield the following results. The Rf values and colour of the spots were recorded

contained 1 mL of the eluate, 400 mL of 218 12.5 mM 3-(dimethylamino) benzoic acid in 0.375 M phosphate buffer (pH 6.5), 80 mL 219 of 3-methyl-2-benzothiazoline hydrazone and 20 mL of peroxidase (0.25 unit). The 220 reaction was started by the addition of peroxidase and the increase in absorbance was

important to humans and most other animals and act as anti-aging, repairing cells, improving human immunity and preventing carcinogenesis but toxicity occurs when taken in large quantity. It is also a basic component of various enzymes such as glutathione peroxidase (GSH-Px) and thioredoxin reductase (TR), which involve in the antioxidant protection of cells (Rotruck et al., 1973; Birringer et al., 2002). Deficiency

Selenium - The Element In 1817, Jöns Jacob Berzelius found out an unknown substance with properties similar to that of tellurium and named it as Selenium, from the Greek word Selene, which denotes goddess of the moon1. Selenium is one of the rarest elements that are found naturally in the earth’s crust. It occupies group 16 (chalcogens) of the periodic table of elements with atomic number 34 and symbol Se. Selenium exists in multiple allotropic forms but only three are recognised. The most stable

enzymes, superoxide dismutase, glutathione reductase, glutathione s-transferase, and glutathione peroxidase and actual glutathione levels in the body substantially. This can reverse disrupted oxidative phosphorylation (OXPHOS) in the mitochondria. Disruption of ATP causes cells to revert to enzymatic ATP production through aerobic glycolysis in the cytoplasm, a process that can convert normal cells into cancer cells. Therefore, it’s an increase in enzymes and glutathione that helps to reverse the disrupted

These free radicals interacts with fatty acids of lung cell membrane and increase lipid peroxidation and DNA fragmentation. Moreover, they suppress antioxidant enzymes including catalase, superoxide dismutase, glutathione (GSH), oxidized glutathione (GSSG), glutathione reductase and glutathione peroxide (1,2,4).

1. Introduction Liver disease represents a considerable public health burden that involves several etiologies overlapping symptoms (El-Serag & Rudolph, 2007). Since the seventies, the experimental model of carbon tetrachloride (CCl4) hepatotoxicity have been closely studied using in vivo models of acute and chronic liver injury. This process has been used comprehensively to examine the pathogenesis of liver injury such as centrilobular steatosis, inflammation, apoptosis and necrosis. CCl4 deteriorates

Hypoxia: is the lack of adequate oxygen but hypoxic injury is due to low blood supply, which impacts the heart muscle (Huether & McCance, 2012, p. 63-65 ). After the cessation of blood supply to the heart muscle, the contraction stops due to decline in mitochondrial phosphorylation. This leads to low ATP production, which causes an increase in anaerobic metabolism, producing ATP from glycogen. Even when that is used up, the sodium and potassium pump on the plasma membrane and the sodium-calcium exchange

prompted many researches to determine which form of selenium supplementation for dietary purposes would be the most efficient in the nutrition of farm animal. The importance of Se is mainly related with its role as an essential part of the glutathione peroxidases (GSH-Px) which supply a defence against oxidative stress by catalyzing the reduction of organic hydroperoxides that react with the selenol group of selenocysteine (Hardy and Hardy, 2004). Consequently an adequate intake of Se is needed to

mineral also aids protein production which is a key role in preventing cell damage. It has also been known that the antioxidant action of selenium can serve as protection against cancer. Selenium is an active part of a group of enzymes called glutathione peroxidases which are crucial to preserving and regaining human

3. Review of Literature 3.1 Parkinson’s Disease7 Parkinson's disease (PD) is a neurodegenerative disease comprising of a spectrum of motor as well as non-motor manifestations. The classic motor manifestations of the disease include rigidity, rest tremors, bradykinesia and impairment of the gait. Along with these cardinal features of Parkinson’s disease, freezing of gait, postural instability, speech difficulty, autonomic disturbances, sensory alterations, mood disorders, sleep dysfunction, cognitive

therapy (Butt, et al.، 2014). In hypertensive patients, lycopene has found to reduce the levels of lipid peroxide malondialdehyde (MDA) at the same time as restore the antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reduced glutathione (GSH). In addition, lycopene significantly effective to reduce MDA and rising GSH levels in coronary artery disease (Misra, et al.,

5.1 Introduction In the brain, the hippocampus is involved in directing the process of creating, systematising and retaining memories. The hippocampus is widely connected to the dorso medial nuclei of the thalamus, mammillary nuclei of the hypothalamus, limbic system network for learning and continuous action for long-term storage. The hippocampus brings about the representation of spatial and temporal memories (Eichenbaum et al, 1992). The research about cognitive function of the hippocampus

Abstract: Valproate (VPA) is a widely used anticonvulsant drugs; however, it represents a typical example of drug-induced adverse reactions especially liver injury. The polyunsaturated, omega-3 fatty acid, docosahexaenoic acid (DHA), prerogatives diverse cytoprotective effects, even though mechanism remains unclear. We have previously demonstrated a protective effect of DHA against VPA-induced hepatotoxicity. Therefore, this study was designed to investigate potential mechanisms of DHA in subsiding

America, it was evident that high blood levels of beta-carotene could protect the body against lung cancer, melanoma and bladder cancer. This study was performed at John Hopkins School of Hygiene and Public Health in Baltimore. The above studies show similar results pointing to the fact that people with high intakes of beta-carotene have a reduced risk of cancer and heart disease. The reason? Beta-carotene stimulates a molecule that helps the immune system destroy cancer cells. It increases the