To do this we have to follow and conduct the experiments given in the BP, such as infrared spectrophotometry, limit testing for p-aminophenol in acetaminophen and running the assay for Acetaminophen and only after these 3 tests can we confidently conclude if the sample is up to standard. Introduction Identification by IR IR is a very specific method for identification of active ingredients in pharmaceutical products. An IR spectrum of the active ingredient should be an exact
Another mechanism of action is the altering of expression and phosphorylation of member of the bcl-2 family of proteins, docetaxel associate with the phosphorylation and inactivation of bcl-2 protein, members of the bcl-2 family are highly conserved proteins which regulate apoptosis. Docetaxel can display a wide spectrum of anti-cancer activity in preclinical trials. The clinical trial has shown that docetaxel is effective against hormone refractory prostate
Moles extrapolated from the titration curve were used to find the molecular weight of the unknown amino acid, along with the pkas and the pI. This information when compared to the literature values of Gly, L-ala, L-ser, and L-asp (of which the unknown was one of) led to the conclusion that the identification of unknown C was likely to be L-Aspartic Acid. The literature values agreed with some deviance from the experimental values, which were likely due to experimental errors. This showed that we can prepare a buffer using an amino acid and use the titration curve of that buffer to identify the unknown amino acid. Results Data
In the present study ,The behavioral effects induced by harmine in rats reported are in coincidence with the literature data, which support an antidepressant action for harmine in basic studies wich could be due to interactions of harmine and related alkaloids s with several receptor systems act as agonists at serotonin receptors [61, 62; 63] ; involved in the modulation of behavioral and molecular actions of antidepressants. [62, 64,65, 28,29]. B carbolines, mainly harmine and harmaline, inhibit MAO activity , Furthermore, as MAO inhibitors, ß-carbolines can increase the level of serotonin in the brain ,and are capable of inducing direct psychoactive effects [69,70].  also suggested that harmine augments dopamine efflux via a novel shell-specific, presynaptic 5-HT2A receptor dependent mechanism, independent of MAO inhibitory activity. Consistent with previous studies in which 40 day of CMS and in the forced swimming test significantly induced depressive-like behavior in rats [26,72], the results of the present study also showed that chronic mild stress induced significant depressive-like behavior, including decreased sacarose solution intake.
COMPARATIVE STUDY OF EFFICACY AND TOXICITY OF IMATINIB AND NILOTINIB BASED REGIMENS IN CML PATIENTS ABSTRACT: CML, a type of myeloproliferative disorder in which proliferation of bone marrow stem cells is found. Chronic phase, accelerated phase & blast crises are 3 phases of CML.Overall 90% of patients with CML Philadelphia chromosomes are present as a result of a t (9; 22) reciprocal translocation. This chromosomal abnormality is detected by cytogenetics, FISH (fluorescent in situ hybridization). BCR -ABL contains a protein that plays an important role in development of leukemia & it is BCR-ABL oncogene. Imatinib & Nilotinib are used for its treatment.
In order to compare the adjuvant activity of compound mucosal immune adjuvant (cMIA), two novel compound adjuvants (cMIA I and cMIA II) were prepared and mixed with Newcastle-disease (ND) vaccine. The humoral and cellular immune responses were determined by means of hemagglutination inhibition test, enzyme linked immunosorbent assay, semi-quantitative RT-PCR, immunohistochemical examination and histological examination. The results showed that two compound adjuvants could promote CD3+ T lymphocytes, IgA secreting cells, intestinal intraepithelial lymphocytes (iIEL) and Mast cells formation and enhance serum and content antibody titer. The best adjuvant activity of cMIA II in promoting cellular immunity and cMIA I in enhancing humoral immunity occurred in whole immune period. Based on good synergistic effects of their components, two cMIAs would be expected as new-type mucosal immune adjuvants for mucosal immune.
1998) of the parasitic cells. The quinine group of ubiquone gets reduced to the quinol and helps in transferring the electron through an oxidation reduction cycle (Tielens A G M and Hellemond J J V 1998; Kroger A. and Gwith M K 1973). Atovaquone too has a quinine group and thus, it can mimic ubiquone and binds selectively to the Q0 site of parasitic mitochondria thereby block the parasitic mitochondrial respiration (Ridley R G 2002). In the present study, we report binding characteristics of trans and cis-isomers of atovaquone with cytochrome bc1 of yeast using docking technique in order to address the basic question, why trans isomer of atovaquone has much higher drug potency than that of its cis isomer? Recently, Hunte et al reported ( Hunte et al.
Idiosyncrasy- A genetic reaction to a drug. Synergism- When two or more structures or drugs work together. Pharmacodynamics- The study of the physiological and biochemical effects of drugs, including the relationship of their effects and actions of them. Pharmacokinetics- The study of the movement of drugs in the body, including absorption and distribution. Lasix-
The prepared microspheres were characterised for micromeritic properties, drug content, in-vitro release, particle size and shape, drug loading, encapsulation efficiency. The drug release characteristics were determined for the prepared microspheres in phosphate buffer pH 6.8 dissolution media. The rate of drug