Air pollution is the result of the emission of chemicals, particulate matter, and biologic material into the atmosphere then caused adverse effect on environment and health. Major air pollutants that threatening human health are carbon monoxide, nitrogen oxide, ozone, chemical vapors, and particulate matter. Air pollution is an important risk factor for cardiovascular health, therefore In this review article, we discuss air-polluted particle and the adverse effects of them on cardiovascular disease.
Introduction:
With advances in technology, air pollution has also increased. Air pollution caused mortality and cardiovascular disease in population [1-3]. Studies showed that increased the daily air pollution concentrations associated with myocardial
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Studies showed that nanoparticles like TiO and C caused air pollution, inflammation, skin injury, and lung accumulation [15].
Air pollutants include gaseous pollutants (e.g, carbon mono oxide, ozone, oxides of nitrogen and sulfur dioxide) and particulate matters (PMs). In this review article, we discuss air-polluted particle (include ambient air particles, disel exhaust, ozone and carbon monoxide) and adverse effects of them on cardiovascular disease.
Ambient Particulate Matter
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Exposure of diesel exhaust particles (DEP) used as particulate air pollution models in experimental studies [46, 48]. Experimental studies showed that exposure of air pollution increased leukocyte and erythrocyte numbers, and hematocrit [49-51]. A key mechanism of air pollution relationship to the generation of inflammation and induce oxidative stress [46, 52, 53].
Recently, studies showed that exposed to air pollution induced myocardial inflammation characterized by increased of TNFα and IL1β [54]. Studies showed that emodin adminstraton following DEP decreased cardiac proinflammatory cytokine TNFα and IL1β [55]. Exposed to DEP caused a significant decreased of SOD in heart tissue. Studies showed that exposure of DEP caused shortening of the thrombotic occlusion time in venules and pial arterioles. Also, emodin has protective effect against DEP-induced thrombotic complications in pial arterioles and venules [55].
Clinical studies showed that acute DE inhalation caused systolic blood pressure increasing, vasodilation imapairs, and/or vasoconstriction improves in humans [56, 57]. DE exposure caused moderate changes in HRV and electrocardiography in rats with minimal cardiac hypertrophy
In March 2010 President Obama signed into law the Patient Protection and Affordable Care Act (PPACA). The goal was to make health care more affordable, accessible and improve quality, for seniors, families and businesses. One component of the PPACA is the Hospital Readmission Reduction Program (HRRP). The objective of HRRP is to reduce hospital readmissions for selected disease categories where Centers for Medicare and Medicaid Services (CMS) data shows there is considerable room for improvement. This program creates financial incentives for hospitals to reduce cost, implement quality improvement programs and focus on reducing readmissions, within 30 days of discharge, for people admitted with a diagnosis of acute myocardial infarction, heart failure and pneumonia.
E.g. 99mTc-tetrofosmin (Myoview, GE healthcare), 99mTc-sestamibi (Cardiolite, Bristol-Myers Squibb now Lantheus Medical Imaging). Following this, the heart rate is raised to induce myocardial stress, either by exercise or pharmacologically with adenosine, dobutamine or dipyridamole (aminophylline can be used to reverse the effects of
The Bronx is an incredibly urban and populated area attracting traffic from all over. It is home to waste sites, distribution centers, power plants, and so much more. Though each building gives off a different type of waste, whether it be smog from smokestacks or diesel exhaust from trucks, each of these large sites that exist throughout this small area give off a fine particulate matter known as PM2.5. This matter is essentially what contributes to the difficulty breathing people experience as these tiny particles can become lodged in a person’s lungs over time. Studies have consistently found a strong correlation between PM2.5 and conditions like asthma, lung disease, and heart disease.
Air quality is known to be a key factor in affecting the wellbeing and quality of life of the general populous and there is a large body of knowledge indicating that certain underrepresented groups may be overexposed to air pollution. (Zou et al. 2014). This is an example of the air quality in locations with a lower known location that is associated with poor air
174). Sepsis commonly associates with DIC as a response to systemic inflammation; pro-inflammatory cytokines excessively produce during DIC resulting in damage to the vascular endothelium (Dressler, 2009, p.174). Damaged endothelial cells trigger the release of abundant tissue factors leading to the activation of coagulation extensively (Dressler, 2009, p.174). A great amount of thrombin develops in the circulation that exhausts the natural ability of the body to produce anticoagulants such as anti-thrombin, protein C and protein S (McKane, 2010, p.1051). As a result, fibrin clots interrupt blood flow through tissues and organs leading to hypoperfusion, ischemia, infarction and necrosis (McKane, 2010, p. 1052).
Abstract: Valproate (VPA) is a widely used anticonvulsant drugs; however, it represents a typical example of drug-induced adverse reactions especially liver injury. The polyunsaturated, omega-3 fatty acid, docosahexaenoic acid (DHA), prerogatives diverse cytoprotective effects, even though mechanism remains unclear. We have previously demonstrated a protective effect of DHA against VPA-induced hepatotoxicity. Therefore, this study was designed to investigate potential mechanisms of DHA in subsiding VPA-induced hepatotoxicity. To achieve this goal, three group of age matched male Sprague Dawley rats were used in the current study; control group, VPA-group received VPA alone (500 mg/kg orally ever day) and VPA+DHA group received VPA plus DHA
There’s a vast amount of issues going on in the state of Texas and no one seems to make an innovation. One of the biggest issue in the state of Texas is pollution in our cities. Based on my outside knowledge, no person seems to bother to make a change in our ecosystem. People seem to care less on how our environment’s health is and focus more in themselves, which is causing a more serious problem. Maybe not in that same time, but thorough the years, it’ll not just cause an issue in our environment, but also among ourselves.
The effects on people’s health is that air pollution can cause stroke, heart diseases, lung cancer or asthma. A mother of two boys said “On poor air quality days when my family has to breathe particles and ozone smog, my kids’ asthma gets worse. They cough and even have asthma attacks.” This proves that the air in China is so
The increased venous return results in end-diastolic volume increase, which generates stretching of ventricular muscle fibres causing an increase in stroke
1. Introduction Air pollutin is a public health concern and it has been since the discovery of fire. Incidents and episodes of air pollution have been recorded throughout the history. Air pollution is divided into two, it is the indoor air pollution and the outdoor air pollution. Indoor air pollution is produced in households or at offices by pollutants such as tobacco smoke, household products or pesticides.
Drugs may produce certain effects on the cardiac muscles example ephedrine may increase heartbeat, stimulation of nerve ending in the nervous system is caused by amphetarine drug which produces changes in
Automotive emission related air pollution must be reduced before its effects on health can
Eugenol at the concentrations of 0.2 -20 µm is suggested to be able to produce a dose dependent and reversible vasodilator response that are partially dependent on the endothelium (24). EUG has also found to have a preventive effect on dopamine depression and lipid peroxidation, which can protect depression induced by 6-hydroxyl dopamine (OHDA). Eugenol has prevented depression by decreasing lipid peroxidation and stimulating reduced glutathione (GSH) may lead to a protecting effect (25). TOXICITY of EUGENOL Eugenol is considered safe as a food additive but due to the wide range of different applications and also the extensive use and availability of clove oil; there is a great concern about its toxicity in recent years.
b. Credibility: Air is a necessity to be able to live. But today air becomes an element to kill us slowly. Air pollution is a major problem in the world yet it is not given enough attention to. Cities have higher air pollution compared to provinces because of the inevitable huge number of vehicles and heavily congested areas. According to Eva Ocfemia, the assistant director of the DENR-EMB in 2015, the air pollutant concentration of NCR reached 130 micrograms per cubic meters in terms of total suspended particulates (TSP), higher than the previous year and the safe level.
There are many problems that threatens society and one problem in particular, air pollution is a problem that threatens everyone. Air pollution is the contamination of air with pollutants that are harmful to humans, animals, and the environment. It began to be a problem when humans discovered the uses of fire and then the amount of air pollution exponentially grew after the industrial revolution, and is still a problem even today. The largest causes of air pollution are from human activities such as burning of fossil fuels and gas emissions from manufacturing plants. There are ways that ordinary people can help contribute to prevent air pollution and or else face the dangerous consequences of polluted air.