Acute Kidney Injury Essay

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A Neuro-Immune Approach In Understanding Acute Kidney Injury Abstract Acute kidney injury (AKI) is a significant health concern. The primary causes of AKI are ischemia, sepsis and nephrotoxicity. Acute kidney injury is mediated by both adaptive and innate immune systems. The role of the nervous system in the activation of immune response and vice- versa is becoming a topic of interest in acute kidney injury. The two systems have a different mode of action. While the nervous system is static, its functions are executed by nerve fibers everywhere in the body. The immune system, on the other hand, is largely migratory in its responses using the blood, lymphatic vessels, and lymphoid organs to recruit mediators to sites of interest.…show more content…
CGRP does not directly influence the basal blood pressure, but it is dependent upon factors such as angiotensin II, glucocorticoids, nerve growth factor, and sympathetic nerve reflexes. CGRP receptors cause vascular relaxation through direct action on smooth muscle cells via increasing the cAMP levels [18, 19 pp2]. CGRP also downregulates the expression of acetylacholinestrase at the transcription level [35 pp 1]. Kidney is the second largest known site for CGRP clearance [8147781]. But kidney does not solely account for degradation of CGRP, other more generalized degradative systems such as endothelial-bound enzymes of blood vessels are suspected to be involved [Braslis,1988]. Its vasodilatation effects depend on other processes such as RAAS, oxidative stress and other inflammatory molecules. The feature that distincts CGRP from other vasodilators is its long Page 11 of 14 Page 12 of 14 duration of action. CGRP is involved in increase in inflammation; increase the number of circulating cells and chemotactic factors, neuronal plasticity and synapse formation [17002803][pgi pr]. CGRP is a key regulatory neuropeptide with important roles in immune outcome and inflammatory mediators such as

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