2.2. POLYMER PROFILE
2.2.1 HYDROXY PROPYL METHYLCELLULOSE30
1) Non proprietary Name
BP: Hypromellose, JP: Hydroxy propyl methylcellulose, PhEur: Hypromellosum,
USP: Hypromellose
2 ) Synonyms
Benecel MHPC; E464; hydroxyl propyl methylcellulose; HPMC; Methocel; methyl cellulose propylene glycol ether; methyl hydroxyl propyl cellulose; Metolose.
3) Molecular Weight
Molecular weight is approximately about 10 000–1 500 000.
4) Structural Formula
5) Functional Category
Coating agent, rate-controlling polymer,film-former, for sustained release,stabilizing agent, suspending agent, tablet binder and viscosity increasing agent.
6) Description
Hypromellose is white or creamy-white fibrous or granular powder ,it is odourless and tasteless
7) Typical
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Solubility: Ethyl cellulose is practically insoluble in Glycerin, Propylene glycol, and Water. Ethyl cellulose that contains less than 46.5% of ethoxyl groups is freely soluble in Chloroform, Methyl acetate, and Tetrahydrofuran and in mixtures of aromatic hydrocarbons with ethanol (95%).
8) Stability and Storage Conditions
a) Ethyl cellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis of both dilute and concentrated, and to salt solutions, even though it is more sensitive to acidic materials than are cellulose esters.
b) Ethyl cellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This could be prevented by the use of antioxidant and chemical additives that absorb light in the 230 – 340 nm
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It should not be stored next to oxidizing agents or other peroxides.
9) Incompatibilities
Incompatible with paraffin wax and microcrystalline wax.
10) Safety
a) Ethyl cellulose is not metabolized following oral consumption and is therefore a non calorific substance. Because ethyl cellulose is not metabolized it is not recommended for parenteral products, parenteral use may damage the kidneys.
b) Ethyl cellulose is generally regarded as a non-toxic, non-allergenic, and nonirritating material. 11) Applications in Pharmaceutical Formulation or Technology
Ethyl cellulose is widely used in oral and topical pharmaceutical Formulations. The major use of ethyl cellulose in oral formulations is as a hydrophobic coating agent for tablets and granules. Modified release tablet formulations may also be produced using ethyl cellulose as a matrix former (1Highviscosity grades of ethyl cellulose are used in drug microencapsulation. In tablet formulations, ethyl cellulose may additionally be employed as a binder, the ethyl cellulose being blended dry or wet-granulated with a solvent such as
Abstract: In this experiment, triphenylmethanol was synthesized in two steps. First, the bromobenzene was reacted with dry magnesium turnings to produce Grignard reagent. Second, the Grignard reagent was reacted with methyl benzoate and concentrated sulfuric acid to produce an alcohol. The end result of the experiment was not very successful because only 17% yield of final product triphenylmethanol was recovered, and the final product was impure based on the melting point and the IR spectrum results.
It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl
LidoPro 4%-27.5%, Topical Analgesic, Quantity 121 Refills 0 Day's Supply 34,NDC # 53225102201
Many people want to believe old age will kill them, but more than likely, the killer will come from what they put into their bodies. Every day, people are faced with affecting their own health. To do so, one must be conscious of what their temple receives; this means people must watch what they eat. People must look at the ingredients contained in everyday foods, what those ingredients cause to happen in the body, and the effects the ingredients have on the body, like the ingredient high fructose corn syrup. The amounts of overconsumed and unhealthy contents of high fructose corn syrup (HFCS) need to be replaced by natural sugars.
High Fructose Corn Syrup (HFCS) Over the last couple decades, HFCS has slowly replaced sugar in our diets. Corn subsidies and tariffs on sugar are just a couple of the reasons why high fructose corn syrup is cheaper to produce. HFCS is widely used in processed foods as a sweetener. Unfortunately, high consumption of fructose causes an increase in triglycerides, blood pressure, and inflammation markers .
A control was used to compare the reactant and the product, showing a clear appearance that would indicate an alkene being present. Bromine was added to the reactant 4-methylcyclohexanol, and a reddish-brown color appeared, indicating that no reaction took place. Bromine was then added to the product 4-methylcyclohexene, and the clear appearance of the product remained, concluding that an alkene is indeed present. Discussion Given the results obtained post-experiment, the percent yield was calculated to be about 35.5%, which may suggest that either product was lost at some point during the experiment, or side product was formed.
Conclusion In this lab, the reactivities of different types of hydrogens, including primary, secondary, tertiary aromatic, aliphatic, and benzylic hydrogens, were analyzed. The experiment was conducted twice, simultaneously. One set of test tubes containing bromine, dichloromethane, and one of toluene, ethylbenzene, tert-butylbenzene, cyclohexane, methylcyclohexane, or more dichloromethane (control), were exposed to UV light; the other equal set of test tubes were placed in a fume hood with the light off. This set of test tubes was not fully in the dark.
Wt. Mass Density Appearance 2-methycyclohexanol 0.75 mL 114.19 g/mol 0.93 g/mL Clear colorless liquid 85% Phosphoric acid 1.00 mL Clear
ABSORPTION, DISTRIBUTION AND METABOLISM: Eucalyptol is quickly absorbed from the gastrointestinal tract. It is lipid soluble and absorption is enhanced in the presence of milk. Inhalation of the liquid is directly toxic to the lungs; however there is no data suggesting systemic absorption via lungs 8. Eucalyptol undergoes oxidation in vivo with the formation of hydroxycineole which is Excreted as glucuronide 9.
Toxins are present in everyday life in a variety of places. Ethylene glycol, commonly found in antifreeze and other household products. Ethylene glycol can be toxic to humans, as well as pets. With antifreeze founds in many households, it is common for pets to find and ingest this toxin. Commonly found in garages where antifreeze is kept, the sweet tasting liquid is often was entices pets to drink it up.
My essay will determine if a local chemical manufacturing plant is in compliance with OSHA Methylene Chloride, specializing in paint stripper for the DOD. Occupational health standard establishes requirements for employers to control occupational exposure to methylene chloride. Exposure may occur through inhalation, by absorption through the skin, or through contact with the skin. The standard requires that the employer establish a regulated area where exposure to airborne concentrations of methylene chloride exceeds or can be expected to exceed either the PEL or the STEL. Determine if the plant is using a soy-based stripper that do not contain methylene chloride, N-methylpyrrolidone, or other toxic solvents, when it comes to paint stripping
Confusion and debate over sugar and high fructose corn syrup is a large debatable topic. With all the foods and bread products that high fructose corn syrup has slowly found its way into, especially in all the new energy drinks. HFCS is an altered sweetened product. Natural sugar is an entirely unprocessed ingredient, for example, milk, organic product, and vegetables. A standout between the most widely known everyday sugars is fructose, which is found in natural fruit product (Added).
It is characterized by erythema (redness), papules, pustules, and telangiectases. It occurs on the face over the cheeks
1100 1076.62 C=C stretch 1650-1550 1569.68 Comments for compatibility: All IR spectra of pure compound and its composition with excipients in formulation are same. This indicates that there was no structural change caused by excipients. 7.2 Optimization of Process Variable The preparation procure was accordingly optimized and validated on the basis of following process variable Table 13: Effect of temperature
% Drug content of all the formulations was determined and was found to have a range of 98-100% when UV-Spectrophotometer is used. This shows that drug was dispersed homogenously throughout the gels. The drug content for F13 formulation was found to be higher because of the optimum ethanol concentration. Rheological Studies of the